915363-56-3
中文名稱
8-氯-4-[(3-氯-4-氟苯基)氨基]-6-[[[1-(1-乙基-4-哌啶)-1H-1,2,3-三唑-4-基]甲基]氨基]-3-喹啉甲腈
英文名稱
8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile
CAS
915363-56-3
分子式
C26H25Cl2FN8
分子量
539.43
MOL 文件
915363-56-3.mol
915363-56-3 結(jié)構(gòu)式
基本信息
中文別名
COT/TPL2抑制劑(COT INHIBITOR-2)8-氯-4-[(3-氯-4-氟苯基)氨基]-6-[[[1-(1-乙基-4-哌啶)-1H-1,2,3-三唑-4-基]甲基]氨基]-3-喹啉甲腈
8-氯-4-[(3-氯-4-氟苯基)氨基]-6-[[[1-(1-乙基哌啶-4-基)-1H-1,2,3-三唑-4-基]甲基]氨基]喹啉-3-甲腈
英文別名
Tpl2-IN-34Cot inhibitor-2
COT INHIBITOR2
COT INHIBITOR 2
8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1
8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl]methyl]amino]quinoline-3-carbonitrile
8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile
3-Quinolinecarbonitrile, 8-chloro-4-[(3-chloro-4-fluorophenyl)aMino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]Methyl]aMino]-
所屬類別
有機(jī)原料：氟苯腈系列物理化學(xué)性質(zhì)
沸點(diǎn)713.3±70.0 °C(Predicted)
密度1.45
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: ≥ 100 mg/mL (185.38 mM)
酸度系數(shù)(pKa)8.62±0.10(Predicted)
形態(tài)粉末
顏色Light yellow to green yellow
常見(jiàn)問(wèn)題列表
生物活性
Cot inhibitor-2 是一種有效的，選擇性的，具有口服活性的 cot (Tpl2/MAP3K8) 抑制劑，IC50 為 1.6 nM。Cot inhibitor-2 抑制 LPS 刺激的人全血中 TNF-α 的產(chǎn)生，IC50 為 0.3 μM。靶點(diǎn)
COT/Tpl2
體內(nèi)研究
Cot inhibitor-2 (compound 34) is orally administered in rats with 100 mg/kg dosing and showed a C max of 517 ng/mL (0.89 μM) and AUC of 4841 ng?h/mL. Cot inhibitor-2 is tested in the LPS-induced TNF-α production model in female Sprague-Dawley rats. With a 25 mg/kg po dose, Cot inhibitor-2 inhibits LPS-induced TNF-α production by 83%.