914361-45-8
中文名稱
磷酸咪康唑 L-賴氨酸乙醇
英文名稱
L-Lysine, coMpd. with 4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-1-Methyl-2-[(phosphonooxy)Methoxy]-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile and ethanol (1:1:1) (9CI)
CAS
914361-45-8
更新日期
2023/03/20 15:41:23
分子式
C31H40F2N7O8PS
分子量
739.73
MOL 文件
914361-45-8.mol
914361-45-8 結(jié)構(gòu)式
基本信息
中文別名
磷酸咪康唑 L-賴氨酸乙醇 英文別名
Fosravuconazole L-lysine ethanolateL-Lysine, coMpd. with 4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-1-Methyl-2-[(phosphonooxy)Methoxy]-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile and ethanol (1:1:1) (9CI)
物理化學(xué)性質(zhì)
儲存條件-20°C儲存
溶解度DMSO : 50 mg/mL (67.59 mM; Need ultrasonic)| (insoluble)
形態(tài)Solid
顏色White to yellow
水溶解性Water : < 0.1 mg/mL (ultrasonic)
常見問題列表
生物活性
Fosravuconazole L-lysine ethanolate (BMS-379224 L-lysine ethanolate)，Ravuconazole 的前藥，是一種具有口服活性的廣譜抗真菌劑。Fosravuconazole L-lysine ethanolate 可用于念珠菌病，灰指甲病和寄生蟲病的研究。體外研究
Fosravuconazole has potent in vitro antifungal activity against a wide range of fungal species, including Candida , Aspergillus , and Trichophyton species.
體內(nèi)研究
Fosravuconazole (E-1224; 10-50 mg/kg; oral administration; daily; for 20 days) treatment suppresses the parasitemia and prevents death in mice infected with the T. cruzi Y strain.
| Animal Model: | Swiss female mice (20-24 g) inoculated with trypomastigotes (Y strain). |
| Dosage: | 10 mg/kg, 20 mg/kg, 30 mg/kg, 40 mg/kg, 50 mg/kg |
| Administration: | Oral administration; daily; for 20 days |
| Result: | Suppressed the parasitemia and prevented death. |