91432-48-3
91432-48-3 結(jié)構(gòu)式
基本信息
中文別名
阿斯卡霉素化合物 T14329
英文別名
ascamycin2-Chloro-5'-O-[(L-alanylamino)sulfonyl]adenosine
2-Chloro-5'-O-[[(S)-2-amino-1-oxopropyl]sulfamoyl]adenosine
(+)-5'-O-[[(S)-2-Amino-1-oxopropyl]aminosulfonyl]-2-chloroadenosine
常見問題列表
生物活性
Ascamycin 是一種由鏈霉菌屬 (Streptomyces sp. JCM9888) 產(chǎn)生的 5'-O-磺酰胺核糖核苷抗生素。Ascamycin 對(duì) Xanthomonas 菌具有選擇性的抑菌活性，對(duì) Xanthomonas citri，Xanthomonas oryzae 和 Mycobacterium phlei 的 MIC 值分別為 0.4 μg/mL，12.5 μg/mL 和 12.5 μg/mL。靶點(diǎn)
MIC: 0.4 μg/mL ( Xanthomonas citri ), 12.5 μg/mL ( Xanthomonas oryzae ) and 12.5 μg/mL ( Mycobacterium phlei )
體外研究
The Ascamycin has C2-chloroadenine as the base on C-1' which lacks the chlorine. Ascamycin has a selective antibacterial activity against Xanthomonas species. When Ascamycin is dealanylated, Dealanylascamycin shows a broad antibacterial activity against various Gram-negative and Gram-positive bacteria. Xanthomonas citri is susceptible to Ascamycin by virtue of the Ascamycin-dealanylating enzyme on the cell surface.