910634-41-2
中文名稱
(-)-N-[4-(2,2-二甲基丙?；?-5-[[2-(乙基氨基)乙磺酰胺]甲基]-5-苯基-4,5-二氫-1,3,4-噻二唑-2-基]-2,2-二甲基丙酰胺
英文名稱
(-)-N-[4-(2,2-Dimethylpropanoyl)-5-[[2-(ethylamino)ethanesulfonamido]methyl]-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide
CAS
910634-41-2
分子式
C23H37N5O4S2
分子量
511.7
MOL 文件
910634-41-2.mol
更新日期
2024/11/15 18:20:29
910634-41-2 結(jié)構(gòu)式
基本信息
中文別名
EG5變構(gòu)抑制劑(LITRONESIB)(-)-N-[4-(2,2-二甲基丙?；?-5-[[2-(乙基氨基)乙磺酰胺]甲基]-5-苯基-4,5-二氫-1,3,4-噻二唑-2-基]-2,2-二甲基丙酰胺
英文別名
KF 89617LY 2523355
Litronesib
LY-2523355
KF-89617
(-)-N-[4-(2,2-Dimethylpropanoyl)-5-[[2-(ethylamino)ethanesulfonamido]methyl]-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide
Propanamide, N-[4-(2,2-dimethyl-1-oxopropyl)-5-[[[[2-(ethylamino)ethyl]sulfonyl]amino]methyl]-4,5-dihydro-5-phenyl-1,3,4-thiadiazol-2-yl]-2,2-dimethyl-, (5R)-
物理化學(xué)性質(zhì)
密度1.23±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO : ≥ 50 mg/mL (97.71 mM)
酸度系數(shù)(pKa)9.47±0.40(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
Litronesib (LY2523355) 是一種選擇性的有絲分裂特異性運(yùn)動蛋白 Eg5 抑制劑，具有抗腫瘤的活性。靶點(diǎn)
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Eg5
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體外研究
Litronesib (LY2523355) is a selective Eg5 inhibitor. Litronesib (25 nM) induces cancer cells to death during mitotic arrest, and this needs sustained activation of spindle-assembly checkpoint (SAC).
體內(nèi)研究
Litronesib (LY2523355; 1.1, 3.3, 10, and 30 mg/kg, i.v.) shows antitumor activity in a dose-dependently, and causes a dramatic increase in cancer cells immuno-positive for histone H3 phosphorylation in Colo205 xenograft tumors.