909910-43-6
909910-43-6 結(jié)構(gòu)式
基本信息
A 83-01, >=98%
A 83-01
A83-01
A-83-01AB142092)
ALK5 Inhibitor IV
TGF inhibitor A-83-01
TGF-β RI Kinase Inhibitor IV
A83-01
A-83-01
A8301
A-8301
A 8301
TGF-β RI Kinase Inhibitor IV - CAS 909910-43-6 - Calbiochem
3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | S7692 | 3-(6-甲基-2-吡啶基)-N-苯基-4-(4-喹啉基)-1H-吡唑-1-硫代甲酰胺 A-83-01 | 909910-43-6 | 5mg | 770元 |
| 2024/11/08 | S7692 | A-83-01 | 909910-43-6 | 1mg*5 | 794.43元 |
| 2024/11/08 | S7692 | 3-(6-甲基-2-吡啶基)-N-苯基-4-(4-喹啉基)-1H-吡唑-1-硫代甲酰胺 A-83-01 | 909910-43-6 | 25mg | 2583.54元 |
常見問題列表
| Target | Value |
|
ALK7
(Cell-free assay) | 7.5 nM |
|
ALK5
(Cell-free assay) | 12 nM |
|
ALK4
(Cell-free assay) | 45 nM |
A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, reduces the level of ALK-5-induced transcription with an IC 50 of 12 nM in Mv1Lu cells, also blocks the ALK4-TD and ALK7-TD induced transcription with IC 50 s of 45 nM and 7.5 nM in R4-2 cells, and weakly suppresses that induced by constitutively active ALK-6, ALK-2, ALK-3, and ALK-1. A 83-01 (0.03-10 μM) potently prevents the growth-inhibitory effects of TGF-β, and completely inhibits the effect at 3 μM. A 83-01 (1-10 μM) inhibits TGF-β-induced Smad activation in HaCaT cells. A 83-01 (1 μM) decreases cell motility, adhesion and invasion increased by TGF-β1 in HM-1 cells, but does not change cell proliferation.
A 83-01 (50, 150 and 500 μg/mouse, i.p.) significantly improves survival of the mice without body weight or neurobehavioral appearances. A 83-01 (0.5 mg/kg, i.p.) shows a significantly strong antitumor effect in mice bearing M109 cells.