890819-86-0
中文名稱
890819-86-0
英文名稱
ML349
CAS
890819-86-0
分子式
C23H22N2O4S2
分子量
454.56
MOL 文件
890819-86-0.mol
更新日期
2023/04/17 13:32:52
890819-86-0 結(jié)構(gòu)式
基本信息
中文別名
APT-2抑制劑(ML349) 英文別名
ML349ML349 >=98% (HPLC)
(5,5-Dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]methanone
Methanone, (5,5-dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]-
所屬類別
生物化工:抑制劑物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : 20 mg/mL (44.00 mM; Need ultrasonic)
形態(tài)粉末
顏色White to yellow
常見問題列表
生物活性
ML349 是一個(gè)有效且特異的酰基蛋白硫酯酶 2 (APT-2) 抑制劑,其 Ki 值為 120 nM。ML349 也是 LYPLA2 的抑制劑,其 IC50 值為 144 nM。靶點(diǎn)
Ki: 120 nM (APT-2)
IC50: 144 nM (LYPLA2)
體外研究
ML349 is an inhibitor of acyl protein thioesterase 1 and 2 (APT-1 and APT-2) with K i s of >10000 and 120±20 nM, respectively. ML349 is also an inhibitor of both LYPLA1 and LYPLA2 with IC 50 s of >3000 and 144 nM, respectivley. ML348 and ML349 do not decrease cell viability, but they lead to a slight activation of AKT in NRAS mutant cells.