888042-13-5
中文名稱
Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-4,6-dimethoxy-6'-methyl-2'-(phenylmethoxy)-, (1'S,6'R)-
英文名稱
Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-4,6-dimethoxy-6'-methyl-2'-(phenylmethoxy)-, (1'S,6'R)-
CAS
888042-13-5
分子式
C23H21ClO6
分子量
428.86
MOL 文件
888042-13-5.mol
888042-13-5 結(jié)構(gòu)式
基本信息
中文別名
化合物 T11395 英文別名
GF 15Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-4,6-dimethoxy-6'-methyl-2'-(phenylmethoxy)-, (1'S,6'R)-
常見問題列表
生物活性
GF 15是有效的中心體聚集 (centrosomal clustering) 抑制劑，可抑制腫瘤細胞的生長。靶點
Centrosomal clustering
體外研究
GF 15 leads to multipolar mitosis induction with an EC 50 of 900 nM. GF 15 exhibits potent cytotoxicity in a concentration-dependent manner against a broad spectrum of tumor cell types including colon, cervix, glioblastoma, pancreas, leukemia, and myeloma-derived cell lines with IC 50 s of 1-5 μM.
體內(nèi)研究
Treatment of mouse xenograft models of human colon cancer and multiple myeloma with GF 15 results in tumor growth inhibition and significantly prolonged survival.