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887603-94-3

中文名稱(chēng) 887603-94-3
英文名稱(chēng) ST101
CAS 887603-94-3
分子式 C15H12N2O
分子量 236.27
MOL 文件 887603-94-3.mol
更新日期 2024/11/15 18:20:28
887603-94-3 結(jié)構(gòu)式 887603-94-3 結(jié)構(gòu)式

基本信息

中文別名
1',3'-二氫-2H-螺[咪唑并[1,2-A]吡啶-3,2'-茚]-2-酮
英文別名
ST101
ZSET 1446
ST 101(ZSET1446)
ST101
ZSET-1446
ZSET 1446
ST-101
ST 101
1,3-DIHYDRO-2H-SPIRO[IMIDAZO[1,2-A]PYRIDINE-3,2-INDEN]-2-ONE
Spiro[imidazo[1,2-a]pyridine-3(2H),2'-[2H]inden]-2-one, 1',3'-dihydro-
所屬類(lèi)別
生物化工:激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

沸點(diǎn)403.4±55.0 °C(Predicted)
密度1.32±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : ≥ 34 mg/mL (143.90 mM)
酸度系數(shù)(pKa)3.13±0.20(Predicted)
形態(tài)Solid
顏色Light yellow to khaki

常見(jiàn)問(wèn)題列表

生物活性
ZSET1446 是一種新穎的促進(jìn)認(rèn)知藥,在不同的阿爾茨海默病模型中,能夠改善學(xué)習(xí)功能障礙。
體外研究

ZSET1446 (100 pM-10 nM) exerts limited effects on the basal neuronal excitability and synaptic transmission. ZSET1446 potentiates the facilitatory effect of nAChR stimulation on sPSC frequency. ZSET1446 potentiates the increase in sIPSC frequency by local application of nicotine (5 μM; 2 minutes) without affecting the basal sIPSC frequency at the range of 10 pM to 1 nM.

體內(nèi)研究

ZSET1446 enhances object recognition memory in mice and ameliorates cognitive impairment caused by scopolamine in rats. Concomitant administration of subeffective doses of ZSET1446 and memantine significantly ameliorates the cognitive performance in the novel object recognition task in both mice and rats. Moreover, oral administration of ZSET1446 or memantine increases the extracellular level of ACh in the hippocampus as compared with the control. Further, concomitant administration of subeffective doses of ZSET1446 and memantine significantly increases the extracellular level of ACh as compared with the group of ZSET1446 or memantine alone. ZSET1446 (0.002, 0.01, and 0.1 mg/kg, p.o.) ameliorates cognitive deficits of SAMP8 after 4, 8, 12, and 16 weeks of treatment in a novel object recognition test. ZSET1446 also reduces grading scores of SAMP8 after 16 weeks of treatment. Further, 8-week treatment of ZSET1446 significantly reduces the total number of Aβ-positive granules in the hippocampus.

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