886230-77-9
中文名稱(chēng)
(E)-6-碘-3-[2-(吡啶-2-基)乙烯基]-1-(四氫-2H-吡喃-2-基)-1H-吲唑
英文名稱(chēng)
(E)-6-Iodo-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
CAS
886230-77-9
分子式
C19H18IN3O
分子量
431.27
MOL 文件
886230-77-9.mol
更新日期
2024/12/23 09:33:17
886230-77-9 結(jié)構(gòu)式
基本信息
中文別名
(E)-6-碘-3-[2-(吡啶-2-基)(E)-6-碘-3-(2-(吡啶-2-基)乙烯基)-1-
(E)-6-碘-3-[2-(吡啶-2-基)乙烯基]-1-(四氫-2H-吡喃-2-基)-1H-吲唑
(E)-6-碘代-3-(2-(吡啶-2-基)乙烯基)-1-(四氫-2H-吡喃-2-基)-1H-吲唑
(E)-6-碘-3-[2-(吡啶-2-基)乙烯基]-1-(四氫-2H-吡喃-2-基)-1H-吲唑 阿西替尼中間體
(E)-6-碘-3-[2-(吡啶-2-基)乙烯基]-1-(四氫-2H-吡喃-2-基)-1H-吲唑 阿西替尼中間體 1KG
英文別名
6-iodo-1-(oxan-2-yl)-3-(2-pyridin-2-ylethenyl)indazole(E)-6-iodo-3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)
6-Iodo-3-(2-pyridin-2-yl-vinyl)-1-(tetrahydro-pyran-2-yl)-1H-indazole
6-iodo-3-((E)-2-(pyridin-2-yl-vinyl) -1-(tetrahydropyran-2-yl)-1H-indazole
(E)-6-iodo-3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
6-Iodo-3-[(1E)-2-(2-pyridinyl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-Indazole
(E)-6-Iodo-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
(E)-6-LODO-3-{2-(PYRIDIN-2-YL)ETHENYL}-1-(TETRAHYDRO-2H-PYRAN-2-YL)-1H-INDAZOLE
1H-Indazole, 6-iodo-3-[(1E)-2-(2-pyridinyl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-
(E)-6-iodo886230-77-9-3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
所屬類(lèi)別
醫(yī)藥中間體物理化學(xué)性質(zhì)
熔點(diǎn)156-159°C
沸點(diǎn)561.2±50.0 °C(Predicted)
密度1.60
儲(chǔ)存條件Keep in dark place,Sealed in dry,2-8°C
溶解度可溶于氯仿、DMSO、甲醇
酸度系數(shù)(pKa)4.25±0.10(Predicted)
形態(tài)固體
顏色淡黃色
穩(wěn)定性有吸濕性、光敏性
InChIInChI=1S/C19H18IN3O/c20-14-7-9-16-17(10-8-15-5-1-3-11-21-15)22-23(18(16)13-14)19-6-2-4-12-24-19/h1,3,5,7-11,13,19H,2,4,6,12H2/b10-8+
InChIKeyQXJFRDDGGSSQDX-CSKARUKUSA-N
SMILESN1(C2OCCCC2)C2=C(C=CC(I)=C2)C(/C=C/C2=NC=CC=C2)=N1
常見(jiàn)問(wèn)題列表
用途
(E)-6-碘-3-[2-(吡啶-2-基)乙烯基]-1-(四氫-2H-吡喃-2-基)-1H-吲唑作為醫(yī)藥中間體，用于合成阿西替尼的原材料。
用途
(E)-6-碘-3-[2-(吡啶-2-基)乙烯基]-1-(四氫-2H-吡喃-2-基)-1H-吲唑是用于制備阿昔替尼的中間體（A794650）作為酪氨酸激酶抑制劑。阿昔替尼用于癌癥治療。