885066-67-1
中文名稱
2-(3-(6-(2-(2,4-二氯苯基)乙基氨基)-2-甲氧基嘧啶-4-基)苯基)-2-甲基丙酸
英文名稱
PGD2-inhibitor
CAS
885066-67-1
分子式
C23H23Cl2N3O3
分子量
460.35
MOL 文件
885066-67-1.mol
更新日期
2024/12/23 09:08:17
885066-67-1 結(jié)構(gòu)式
基本信息
中文別名
化合物PGD2-INHIBITOR2-(3-(6-(2-(2,4-二氯苯基)乙基氨基)-2-甲氧基嘧啶-4-基)苯基)-2-甲基丙酸
英文別名
MDK66671PGD2-IN-1
PGD2-inhibitor
PGD2 inhibitor 1
PGD2-IN-1?, >98%
PGD2-inhibitor, >98%
prostaglandin D2(PGD2) inhibitor
Benzeneacetic acid, 3-[6-[[2-(2,4-dichlorophenyl)ethyl]amino]-2-methoxy-4-pyrimidinyl]-α,α-dimethyl-
所屬類別
生物化工：激動劑抑制劑物理化學(xué)性質(zhì)
沸點682.1±65.0 °C(Predicted)
密度1.326±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO : ≥ 25 mg/mL (54.31 mM)
酸度系數(shù)(pKa)4.09±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
PGD2-IN-1 是DP受體拮抗劑, 來自專利專利WO 2006044732 A2，化合物實例15 (d)， IC50值為0.3 nM。靶點
IC50: 0.3 nM
體外研究
Prostaglandin D2 (PGD2) is a major inflammatory mediator implicated in asthma and allergic rhinitis. It is largely produced as the major cyclooxygenase metabolite upon allergen-provoked degranulation from mast cells. Blockage of PGD2 using DP antagonists has been shown to be effective at alleviating the symptoms of allergic rhinitis in multiple species and more specifically has been shown to inhibit the antigen-induced nasal congestion.