883031-03-6
883031-03-6 結(jié)構(gòu)式
基本信息
HC-067047 >=98% (HPLC)
HC-067047
HC 067047
HC067047
1221277-90-2
2-methyl-1-(3-morpholin-4-ylpropyl)-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamide
2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
1H-Pyrrole-3-carboxamide, 2-methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-
物理化學(xué)性質(zhì)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-100208 | 883031-03-6 HC-067047 | 883031-03-6 | 5mg | 660元 |
| 2024/11/08 | HY-100208 | 883031-03-6 HC-067047 | 883031-03-6 | 10mM * 1mLin DMSO | 685元 |
| 2024/11/08 | HY-100208 | 883031-03-6 HC-067047 | 883031-03-6 | 10mg | 1100元 |
常見問題列表
| Target | Value |
|
mTRPV4
(Cell-free assay) | 17 nM |
|
hTRPV4
(Cell-free assay) | 48 nM |
|
rTRPV4
(Cell-free assay) | 133 nM |
HC-067047 (1 μM; 24 hours; HEI-OC1 cells) treatment significantly decreases mRNA expression in high glucose cultured HEI-OC1 cells.
HC-067047 (1 μM; 24 hours; HEI-OC1 cells) treatment significantly decreases the expression of TRPV4 protein.
HC-067047 (1 μM; 48 hours; HEI-OC1 cells) treatment inhibits cell proliferation.
HC-067047 (1 μM; 48 hours; HEI-OC1 cells) treatment promotes cell apoptosis.
RT-PCR
| Cell Line: | HEI-OC1 cells |
| Concentration: | 1 μM |
| Incubation Time: | 24 hours |
| Result: | The mRNA expression was significantly decreased. |
Western Blot Analysis
| Cell Line: | HEI-OC1 cells |
| Concentration: | 1 μM |
| Incubation Time: | 24 hours |
| Result: | The expression of TRPV4 protein was significantly decreased. |
Cell Proliferation Assay
| Cell Line: | HEI-OC1 cells |
| Concentration: | 1 μM |
| Incubation Time: | 48 hours |
| Result: | Inhibited cell proliferation. |
Apoptosis Analysis
| Cell Line: | HEI-OC1 cells |
| Concentration: | 1 μM |
| Incubation Time: | 48 hours |
| Result: | Promoted cell apoptosis. |
HC-067047 (0-50 mg/kg; intraperitoneal injection; for 30 minutes; cyclophosphamide-treated WT and Trpv4 ?/? mice, and naive WT mice) treatment increases functional bladder capacity and reduces micturition frequency in WT mice with cystitis. HC-067047 do not affect bladder function in Trpv4 ?/? mice.
| Animal Model: | Cyclophosphamide-treated WT and Trpv4 ?/? mice, and naive WT mice |
| Dosage: | 0 mg/kg, 1 mg/kg, 10 mg/kg, 50 mg/kg |
| Administration: | Intraperitoneal injection; for 30 minutes |
| Result: | Increased functional bladder capacity and reduces micturition frequency in WT mice with cystitis and did not affect bladder function in Trpv4 ?/? mice. |