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878143-03-4

中文名稱(chēng) 878143-03-4
英文名稱(chēng) Phosphonic acid, [(3E)-1-[(2E)-3,7-dimethyl-2,6-octadienyl]-4,8-dimethyl-3,7-nonadienylidene]bis-, tetrasodium salt
CAS 878143-03-4
分子式 C21H34Na4O6P2
分子量 536.398
MOL 文件 878143-03-4.mol
878143-03-4 結(jié)構(gòu)式 878143-03-4 結(jié)構(gòu)式

基本信息

中文別名
化合物 T12452
英文別名
DGBP
Digeranyl bisphophonate
Digeranyl bisphosphonate
Phosphonic acid, [(3E)-1-[(2E)-3,7-dimethyl-2,6-octadienyl]-4,8-dimethyl-3,7-nonadienylidene]bis-, tetrasodium salt

物理化學(xué)性質(zhì)

儲(chǔ)存條件Store at -20°C, protect from light, stored under nitrogen
溶解度DMSO : 2 mg/mL (3.73 mM; Need ultrasonic)|
形態(tài)Solid
顏色White to off-white
水溶解性Water : 2 mg/mL (3.73 mM; Need ultrasonic)
878143-03-4價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2024/11/08HY-U00145878143-03-4
Digeranyl bisphosphonate
878143-03-41mg3200元
2024/08/19HY-U00145878143-03-4
Digeranyl bisphosphonate
878143-03-45mg6400元
2023/03/20HY-U00145878143-03-4
Digeranyl bisphosphonate
878143-03-410mg12240元

常見(jiàn)問(wèn)題列表

生物活性
Digeranyl bisphosphonate (DGBP) 是一種有效的香葉基焦磷酸香葉酯 (GGPP) 合酶抑制劑,其抑制 Rac1 的香葉酰香葉?;?。
靶點(diǎn)

Rac1

體外研究

Digeranyl bisphosphonate (DGBP) impairs geranylgeranylation. To examine if Digeranyl bisphosphonate modulates Rac1 activity, cells are exposed to vehicle or Digeranyl bisphosphonate. Rac1 activation increases significantly after chrysotile exposure, whereas the activity in Digeranyl bisphosphonate -treated cells is reduced to control levels. Digeranyl bisphosphonate also decreases H 2 O 2 generation in chrysotile-exposed macrophages.

體內(nèi)研究

To further evaluate the effect of Digeranyl bisphosphonate (DGBP; 0.2 mg/kg/day) in protecting mice from chrysotile-induced pulmonary fibrosis, the mice are administered vehicle or Digeranyl bisphosphonate subcutaneously in osmotic pumps, and exposed to saline or chrysotile the following day. Mice exposed to saline have normal lung architecture with vehicle and Digeranyl bisphosphonate treatment. Chrysotile-exposed mice that receive vehicle have significant architectural changes in their lung parenchyma and large amounts of collagen deposition, whereas the lungs of the Digeranyl bisphosphonate -treated mice are essentially normal. To investigate the effect of Digeranyl bisphosphonate in Bleomycin-induced fibrosis, osmotic pumps containing either vehicle or Digeranyl bisphosphonate are implanted subcutaneously in WT mice. Mice are exposed to saline or Bleomycin the following day. Digeranyl bisphophonate (0.2 mg/kg/day)-treated mice show significantly less hydroxyproline compared to vehicle-treated mice exposed to Bleomycin.

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