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876708-03-1

中文名稱 4-氨基-1-(4-C-疊氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮
英文名稱 RO 9187
CAS 876708-03-1
分子式 C9H12N6O5
分子量 284.229
MOL 文件 876708-03-1.mol
更新日期 2023/09/08 15:48:11
876708-03-1 結構式 876708-03-1 結構式

基本信息

中文別名
4-氨基-1-(4-C-疊氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮
英文別名
RO 9187
RO 9187
RO9187
4-Amino-1-(4-C-azido-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone
所屬類別
生物化工:激動劑抑制劑

物理化學性質

熔點188.0-189.0℃
儲存條件-20°C儲存
溶解度H2O : 7.14 mg/mL (25.12 mM; Need ultrasonic)
形態(tài)粉末
顏色Light yellow to yellow
4-氨基-1-(4-C-疊氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-108704-氨基-1-(4-C-疊氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮
RO-9187
876708-03-15mg2000元
2024/11/08HY-108704-氨基-1-(4-C-疊氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮
RO-9187
876708-03-110 mM * 1 mLin DMSO2200元
2024/11/08HY-108704-氨基-1-(4-C-疊氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮
RO-9187
876708-03-110mg3400元

常見問題列表

生物活性
RO-9187是高效的HCV病毒復制抑制劑,IC50值為171 nM。
靶點

IC50: 171 nM (HCV)

體外研究

RO-9187 is excellent substrates for deoxycytidine kinase and is phosphorylated with efficiencies up to 3-fold higher than deoxycytidine. RO-9187 inhibits RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations with similar potencies, suggesting no cross-resistance with either R1479 (4′-azidocytidine) or 2′-C-methyl nucleosides. The formation of RO-9187-TP increased in a time- and dose-dependent manner. The maximal triphosphate concentration at 24 h is 87 pmol/106 cells with half-maximal triphosphate formation achieved at 12 μM RO-9187.

體內(nèi)研究

Plasma exposures of RO-9187 in rats increase in a dose-dependent manner between 10 and 2000 mg/kg after oral dosing. Plasma concentrations of 1.4 and 26 μM (390 and 7454 ng/mL) are achieved in rats and dogs at the 10 mg/kg dose level, respectively. Plasma concentrations up to 57 μM are achieved in rats dosed with 2000 mg/kg/day.

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