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866893-90-5

中文名稱 866893-90-5
英文名稱 Aftin-4
CAS 866893-90-5
分子式 C20H28N6O
分子量 368.48
MOL 文件 866893-90-5.mol
更新日期 2024/12/15 19:35:15
866893-90-5 結(jié)構(gòu)式 866893-90-5 結(jié)構(gòu)式

基本信息

中文別名
化合物AFTIN4
英文別名
Aftin-4
Aftin-4 >=98% (HPLC)
AFTIN-4
AFTIN 4
AFTIN4
N6-methyl-(R)-roscovitine
1-Butanol, 2-[[9-(1-methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)-

物理化學性質(zhì)

儲存條件-20°C
溶解度可溶于DMSO
形態(tài)粉末
顏色白色至米色

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302
866893-90-5價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-111267866893-90-5
Aftin-4
866893-90-52mg729元
2024/11/08HY-111267866893-90-5
Aftin-4
866893-90-510mM * 1mLin DMSO1054元
2024/11/08HY-111267866893-90-5
Aftin-4
866893-90-55mg1245元

常見問題列表

生物活性
Aftin-4 是 β-淀粉樣蛋白42 (Aβ42) 的誘導劑。
靶點

Amyloid-β

體外研究

Aftin-4 selectively and potently increases Aβ 1-42 in N2a cells, primary neurons, and brain lysates, with an EC 50 value around 30 μM.

體內(nèi)研究

Aftin-4 increases Aβ 1-42 levels in vivo in mice and provokes rapidly a sustained toxicity highly reminiscent of Alzheimer’s disease (AD). Aftin-4 is administered at increasing doses, between 3 and 20 nmol/mouse, into the lateral ventricle and animals are sacrificed at various time points, between 3 to 14 days after injection. The hippocampus is dissected out the contents in Aβ 1-40 or Aβ 1-42 is determined using a mouse ELISA assay. Aftin-4 dose-dependently and significantly increases Aβ 1-42 content, up to +216% at the highest dose tested.

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