86583-19-9
物理化學(xué)性質(zhì)
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2024/11/08 | HY-W013332A | 3-DEAZAADENOSINE HYDROCHLORIDE 3-Deazaadenosine hydrochloride | 86583-19-9 | 1mg | 1713元 |
2024/11/08 | HY-W013332A | 3-DEAZAADENOSINE HYDROCHLORIDE 3-Deazaadenosine hydrochloride | 86583-19-9 | 10mM * 1mLin DMSO | 2597元 |
2024/11/08 | HY-W013332A | 3-DEAZAADENOSINE HYDROCHLORIDE 3-Deazaadenosine hydrochloride | 86583-19-9 | 5mg | 3900元 |
常見問題列表
Target | Value |
S-adenosylhomocysteine hydrolase
(Cell-free assay) | 3.9 μM(Ki) |
3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a K i of 3.9 μM. 3-Deazaadenosine shows anti-HIV effect, and inhibits p24 antigen in peripheral blood mononuclear (PBMCs) cells infected with HIV-1 isolates (A012 and A018) with IC 50 s of 0.15 and 0.20 μM, respectively. 3-Deazaadenosine (1-100 μM) inhibits LPS-induced expression of TNF-α mRNA, increases DNA binding activity of NF-κB, and causes proteolytic degradation of IκBα, but Not IκBβ in RAW 264.7 cells. 3-Deazaadenosine (100 μM) enhances nuclear translocation of NF-κB, but blocks LPS-induced NF-κB transcriptional activity, and such inhibition is augmented by the addition of homocysteine. 3-Deazaadenosine (50, 100 μM) dose-dependently inhibits the phosphorylation of Raf and ERK, protein-dependent kinase 1, protein kinase B (Akt), and forkhead transcription factor FoxO1a. 3-Deazaadenosine (50 μM) suppresses vascular smooth muscle cell (VSMC) proliferation via interfering with Ras signaling.