天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>86583-19-9

86583-19-9

中文名稱 3-DEAZAADENOSINE HYDROCHLORIDE
英文名稱 3-Deazaadenosine (hydrochloride)
CAS 86583-19-9
更新日期 2023/03/20 15:41:23
分子式 C11H15ClN4O4
分子量 302.72
MOL 文件 86583-19-9.mol
86583-19-9 結(jié)構(gòu)式 86583-19-9 結(jié)構(gòu)式

基本信息

中文別名
3-脫氮腺苷鹽酸鹽
化合物3-DEAZAADENOSINE HYDROCHLORIDE
英文別名
3-Deazaadenosine (hydrochloride)

物理化學(xué)性質(zhì)

儲存條件-20°C儲存
溶解度DMSO: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
形態(tài)結(jié)晶固體
顏色White to off-white
3-DEAZAADENOSINE HYDROCHLORIDE價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-W013332A3-DEAZAADENOSINE HYDROCHLORIDE
3-Deazaadenosine hydrochloride
86583-19-91mg1713元
2024/11/08HY-W013332A3-DEAZAADENOSINE HYDROCHLORIDE
3-Deazaadenosine hydrochloride
86583-19-910mM * 1mLin DMSO2597元
2024/11/08HY-W013332A3-DEAZAADENOSINE HYDROCHLORIDE
3-Deazaadenosine hydrochloride
86583-19-95mg3900元

常見問題列表

生物活性
3-Deazaadenosine HCl (3-DZA, c3Ado)是一種有效的 S-adenosylhomocysteine hydrolase 的抑制劑,Ki值為3.9 μM。3-Deazaadenosine HCl 可抑制細(xì)菌脂多糖誘導(dǎo)的 TNF-α 和 IL-1β 的轉(zhuǎn)錄。3-Deazaadenosine HCl 可抑制 NF-κB 的轉(zhuǎn)錄活性,阻止FCS誘導(dǎo)的 Ras 的羧基甲基化,并降低FCS誘導(dǎo)的 ERK1/2 和 Akt 磷酸化。3-Deazaadenosine HCl 具有抗炎、抗增殖和抗HIV的活性。
靶點(diǎn)
TargetValue
S-adenosylhomocysteine hydrolase
(Cell-free assay)
3.9 μM(Ki)
體外研究

3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a K i of 3.9 μM. 3-Deazaadenosine shows anti-HIV effect, and inhibits p24 antigen in peripheral blood mononuclear (PBMCs) cells infected with HIV-1 isolates (A012 and A018) with IC 50 s of 0.15 and 0.20 μM, respectively. 3-Deazaadenosine (1-100 μM) inhibits LPS-induced expression of TNF-α mRNA, increases DNA binding activity of NF-κB, and causes proteolytic degradation of IκBα, but Not IκBβ in RAW 264.7 cells. 3-Deazaadenosine (100 μM) enhances nuclear translocation of NF-κB, but blocks LPS-induced NF-κB transcriptional activity, and such inhibition is augmented by the addition of homocysteine. 3-Deazaadenosine (50, 100 μM) dose-dependently inhibits the phosphorylation of Raf and ERK, protein-dependent kinase 1, protein kinase B (Akt), and forkhead transcription factor FoxO1a. 3-Deazaadenosine (50 μM) suppresses vascular smooth muscle cell (VSMC) proliferation via interfering with Ras signaling.

"86583-19-9" 相關(guān)產(chǎn)品信息