864249-60-5
864249-60-5 結(jié)構(gòu)式
基本信息
化合物 AMG-548 DIHYDROCHLORIDE
AMG-548 (AMG548)
AMG-548 dihydrochloride
2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone
4(3H)-Pyrimidinone, 2-[[(2S)-2-amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-
2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone dihydrochloride
安全數(shù)據(jù)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-108642B | AMG-548 AMG-548 dihydrochloride | 864249-60-5 | 1mg | 900元 |
| 2024/11/08 | HY-108642B | AMG-548 AMG-548 dihydrochloride | 864249-60-5 | 5mg | 2700元 |
| 2024/11/08 | HY-108642B | AMG-548 AMG-548 dihydrochloride | 864249-60-5 | 10 mM * 1 mLin DMSO | 3170元 |
常見問題列表
|
p38α 0.5 nM (Ki) |
p38β 3.6 nM (Ki) |
p38δ 2600 nM (Ki) |
p38γ 4100 nM (Ki) |
dog p38α 5.0 nM (Ki) |
JNK1 11480 nM (Ki) |
JNK2 39 nM (Ki) |
JNK3 61 nM (Ki) |
CK1
|
AMG-548 shows >1000 fold selective against p38γ (K
i
=2600 nM) and p38δ (k
i
=4100 nM). AMG-548 has an modest selectivity against JNK2 (k
i
=39 nM) and JNK3 (k
i
=61 nM). AMG-548 is also extremely potent in the inhibition of whole blood LPS stimulated TNFa (IC
50
=3 nM) and IL1b (IC
50
=7 nM) as well as TNFa induced IL-8 (IC
50
=0.7 nM) and IL-1b induced IL-6 (IC50
50
=1.3 nM) in human whole blood.
AMG-548 (10 μM) inhibits the hDvl2 shift.
AMG-548 has rat F of 62% and dog F of 47%. The t 1/2 is 4.6 hours in rats and 7.3 hours in dogs.