86408-36-8
中文名稱
多粘菌素B九肽
英文名稱
POLYMYXIN B NONAPEPTIDE HYDROCHLORIDE
CAS
86408-36-8
分子式
C43H74N14O11
分子量
963.13
MOL 文件
86408-36-8.mol
更新日期
2024/12/22 20:23:43
86408-36-8 結(jié)構(gòu)式
基本信息
中文別名
多粘菌素B九肽多粘菌素B鹽酸鹽
阿維巴坦雜質(zhì)66
英文別名
PMBNsPMBN
2-10-Polymyxin B1
polymyxinbnonapeptide
POLYMYXIN B NONAPEPTIDE HYDROCHLORIDE
N2-(L-Thr-L-A2bu-)Cyclo(L-A2bu*-L-A2bu-D-Phe-L-Leu-L-A2bu-L-A2bu-Thr-)
Nα-(L-Thr-L-A2bu-)Cyclo(L-A2bu*-L-A2bu-D-Phe-L-Leu-L-A2bu-L-A2bu-L-Thr-)
N2-(L-Thr-L-A2bu-)Cyclo(L-A2bu*-L-A2bu-D-Phe-L-Leu-L-A2bu-L-A2bu-L-Thr-)
所屬類別
生物化工：多肽物理化學(xué)性質(zhì)
儲存條件2-8°C
溶解度Water: ≥ 100 mg/mL (103.83 mM); DMSO: 16.67 mg/mL (17.31 mM)
形態(tài)Solid
顏色White to off-white
序列H-Thr-Dab-Dab-Dab-d-Phe-Leu-Dab-Dab-Thr-OH(Lactam: Dab3-Thr10)
常見問題列表
生物活性
Polymyxin B nonapeptide 是一種陽離子環(huán)肽。Polymyxin B nonapeptide 是經(jīng)酶裂解 Polymyxin B 而產(chǎn)生的衍生物，與 Polymyxin B 相比，Polymyxin B nonapeptide 毒性低，缺乏殺菌活性，仍具有破壞革蘭氏陰性菌外膜的能力。體外研究
Polymyxin B nonapeptide, a cationic cyclic peptide derived by enzymatic processing from the naturally occurring peptide polymyxin B, is able to increase the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics probably by binding to the bacterial lipopolysaccharide (LPS).