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850608-87-6

中文名稱 850608-87-6
英文名稱 Riluzole hydrochloride
CAS 850608-87-6
分子式 C8H6ClF3N2OS
分子量 270.66
MOL 文件 850608-87-6.mol
更新日期 2024/11/24 08:19:41
850608-87-6 結(jié)構(gòu)式 850608-87-6 結(jié)構(gòu)式

基本信息

中文別名
化合物 RILUZOLE HYDROCHLORIDE
英文別名
RILUZOLE HCL
RILUZOLE HYDROCHLORIDE
2-AMINO-6-TRIFLUOROMETHOXYBENZOTHIAZOLE HYDROCHLORIDE

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMF: 30 mg/mL; DMSO: 30 mg/mL; Ethanol: 30 mg/mL; Ethanol:PBS (pH7.2)(1:20): 0.04 mg/mL; Water: Soluble
形態(tài)固體
顏色白色
850608-87-6價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-B0211A850608-87-6
Riluzole hydrochloride
850608-87-650mg600元
2024/11/08HY-B0211A850608-87-6
Riluzole hydrochloride
850608-87-610mM * 1mLin DMSO660元
2024/11/08HY-B0211A850608-87-6
Riluzole hydrochloride
850608-87-6100mg960元

常見問題列表

生物活性
Riluzole hydrochloride 是一種抗驚厥藥物,屬于依賴于使用的鈉通道阻滯劑家族,它也可以抑制 GABA 攝取,其 IC50 值為 43 μM。
靶點(diǎn)

Sodium channel IC50: 43 μM (GABA receptor)

體外研究

Riluzole hydrochloride is an anticonvulsant drug and belongs to the family of use-dependent Na + channel blocker which can also inhibit GABA uptake with an IC 50 of 43 μM. At 20 μM, Riluzole hydrochloride inhibits peak autaptic IPSCs only slightly but prolongs IPSCs reliably. It is also found that Riluzole hydrochloride causes a strong, concentration-dependent, readily reversible enhancement of responses to 2 μM GABA. At higher concentrations of Riluzole hydrochloride, especially 300 μM, GABA currents exhibit apparent desensitization during prolonged co-exposure to 2 μM GABA and Riluzole hydrochloride. The EC 50 of Riluzole hydrochloride potentiation of GABA responses is about 60 μM.

體內(nèi)研究

In normal na?ve rats, systemic injection of Riluzole hydrochloride (8 mg/kg, i.p.; n=6 rats) decreases the duration of ultrasonic but not audible vocalizations evoked by noxious stimulation of the knee joint compare to vehicle tested in the same rats (P<0.05). Systemic application of Riluzole hydrochloride (8 mg/kg, i.p.; n=19 rats) decreases the vocalizations of arthritic rats compare to predrug and vehicle significantly (P<0.05 to 0.001). Riluzole hydrochloride administered into the CeA significantly decreases the duration of audible and ultrasonic vocalizations evoked by noxious stimulation of the knee compare to predrug values (n=8 rats; P<0.05 to 0.01).

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