848644-86-0
中文名稱
P11
英文名稱
P11
CAS
848644-86-0
分子式
C30H48N12O9
分子量
720.78
MOL 文件
848644-86-0.mol
更新日期
2024/12/23 10:30:23
848644-86-0 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)1380.0±65.0 °C(Predicted)
密度1.381±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C, protect from light
溶解度Soluble to 1 mg/ml in 20% acetonitrile - 0.1% acetic acid
酸度系數(shù)(pKa)4.17±0.10(Predicted)
形態(tài)粉末
顏色White to off-white
序列H-His-Ser-Asp-Val-His-Lys-NH2
常見問題列表
生物活性
HSDVHK-NH2 是整合素 αvβ3-玻璃體結(jié)合蛋白的互作抑制劑，其 IC50 值為 1.74 pg/mL (2.414 pM)。靶點(diǎn)
|
αvβ3 2.74 nM (IC 50 ) |
體外研究
HSDVHK significantly inhibited bFGF-induced cell migration compared to the PBS control group.
The Arg-Gly-Asp (RGD)-binding site recognition by HSDVHK-NH2 (P11) is site specific because the HSDVHK-NH2 (P11) is inactive for the complex formation of a denatured form of integrin–vitronectin. HSDVHK-NH2 (P11) shows a strong antagonism against avb3-GRGDSP interaction with an IC
50
value of 25.72 nM.
HSDVHK-NH2 (P11) inhibits the HUVEC proliferation due to the induction of HUVEC cell death through caspases activations and its mechanism is related with increased p53 expression.
Cell Proliferation Assay
| Cell Line: | HUVEC cells. |
| Concentration: | 0.1, 1, 10, and 100 μg/mL. |
| Incubation Time: | 72 h. |
| Result: | Significantly inhibited HUVEC proliferation on denatured collagen-coated plates in a dose-dependent manner. |