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84294-96-2

中文名稱 依諾沙星
英文名稱 Enoxacin
CAS 84294-96-2
分子式 C15H17FN4O3.11/2H2O
分子量 694.684
MOL 文件 84294-96-2.mol
更新日期 2024/12/16 11:46:04
84294-96-2 結(jié)構(gòu)式 84294-96-2 結(jié)構(gòu)式

基本信息

中文別名
依諾沙星倍
水合依諾沙星
依諾沙星水合物
依諾沙星半水合物
依諾沙星倍半水合物
依諾沙星(1.5結(jié)晶水合物)
依諾沙星(1.5結(jié)晶水合物) 標(biāo)準(zhǔn)品
1-乙基-6-氟-4-氧代-7-(哌嗪-1-基)-1,4-二氫-1,8-萘啶-3-羧酸倍半水合物
英文別名
Enoxacin sesq
CI-919 hydrate
AT-2266 hydrate
Enoxacin (hydrate)
ENOXACIN SESQUIHYDRATE
EnoxacinSesquihydrate>
Enoxacin hydrate (CI-919)
1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid sesquihydrate
bis(1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-di hydro-1,8-naphthyridine-3-carboxylic acid) trihydrate C30H
所屬類(lèi)別
原料藥:喹諾酮類(lèi)藥

物理化學(xué)性質(zhì)

熔點(diǎn)226 °C
儲(chǔ)存條件Keep in dark place,Inert atmosphere,Room temperature
溶解度可溶于MNaOH:溶解度為50mg/mL,澄清,無(wú)色至淡黃色
形態(tài)neat
顏色White to Off-White
Merck14,3587
穩(wěn)定性Hygroscopic

安全數(shù)據(jù)

安全說(shuō)明24/25
WGK Germany3
海關(guān)編碼29335990
依諾沙星價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08E0762依諾沙星倍半水合物
Enoxacin  Sesquihydrate
84294-96-25G290元
2024/11/08HY-B0268A依諾沙星
Enoxacin hydrate
84294-96-2100mg500元
2024/11/08HY-B0268A依諾沙星
Enoxacin hydrate
84294-96-2500mg800元

常見(jiàn)問(wèn)題列表

生物活性
Enoxacin sesquihydrate (Enoxacin hydrate)是一種廣譜的6-fluoronaphthyridinone抗菌劑。
體外研究

Enoxacin hydrate (Enoxacin sesquihydrate) increases siGFP-mediated gene knockdown mediated by siRNA against EGFP in HEK293 cells-based reporter system in a dose-dependent manner, with a median effective concentration (EC50) of ~30 μM, whereas it has no effect on the cells expressing GFP only. Enoxacin (50 μM) promotes the processing of miRNAs and the loading of siRNA duplexes onto RISCs in HEK293 cells.
Enoxacin has no effect on the processing of pre-let-7 or pre-miR-30a by Dicer alone. However, the addition of Enoxacin can enhance the processing of let-7 or pre-miR-30a by Dicer and TRBP together.
Enoxacin inhibits 90% Escherichia coli, Klebsiella sp., Aeromonas sp., Enterobacter spp., Serratia spp., Proteus mirabilis, and Morganella morganii at less than or equal to 0.8 micrograms/ml.

體內(nèi)研究

Enoxacin hydrate (Enoxacin sesquihydrate; 100 μM; 2 μl; injected into ear once a day for 3 consecutive days (days 12, 13 and 14)) enhances the the GFP mRNA knockdown efficiency by Lv-siGFP (from 80% to 60%; 40% GFP mRNA level remained), whereas alone has no effect on GFP expression in GFP transgenic line C57BL/6-Tg(ACTB-EGFP)1Osb/J (10 d old) with lentivirus expressing shGFP (Lv-siGFP; injected into ear for 10 days).

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