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823218-99-1

中文名稱 CS-1190
英文名稱 SN 2
CAS 823218-99-1
分子式 C17H21NO
分子量 255.35
MOL 文件 823218-99-1.mol
823218-99-1 結(jié)構(gòu)式 823218-99-1 結(jié)構(gòu)式

基本信息

中文別名
化合物SN 2
3-均三甲苯基-3A,4,5,6,7,7A-六氫-4,7-亞甲基苯并[D]異惡唑
英文別名
CS-1190
SN2
SN-2
3a,4,5,6,7,7a-Hexahydro-3-(2,4,6-trimethylphenyl)-4,7-methano-1,2-benzisoxazole
4,7-Methano-1,2-benzisoxazole, 3a,4,5,6,7,7a-hexahydro-3-(2,4,6-trimethylphenyl)-

物理化學(xué)性質(zhì)

沸點(diǎn)370.8±52.0 °C(Predicted)
密度1.27±0.1 g/cm3(Predicted)
儲存條件2-8°C
儲存條件Sealed in dry,2-8°C
溶解度DMSO : 100 mg/mL (391.62 mM; Need ultrasonic)
形態(tài)粉末
顏色White to off-white

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H315-H319

圖譜信息

常見問題列表

生物活性
SN 2 是一種有效的 TRPML3 離子通道激活劑,EC50 為 1.8 μM。SN 2 還是登革熱病毒 2 (DENV2) 和寨卡病毒 (ZIKV) 的有效抑制劑。
靶點(diǎn)

EC50: 1.8±0.13 μM (TRPML3), >29.9 μM (TRPML1)

體外研究

The conductance of TRPML3 channels is estimate, when activated with 10 μM SN-2 is approximately 10 pS at ?80 mV. TRPML3-expressing HEK293 cells are perfused with a series starting with compound alone (in SBS), with compound in ELS, and finally with ELS alone. Two representative compounds, SF-24 and SN-2, are tested. SF-24 is one of the least effective compounds, and SN-2 is one of the most active ones. SN-2 has a similar synergistic effect, also reaching up-to 10-fold enhancement of the combined response when compared with the individual responses, reaching average current densities of up to 3 nA/pF at ?80 mV. Dominant negative TRPML3(D458K) is highly effective in eliminating SN-2-induced activity in epidermal melanocytes, suggesting that SN-2 activates a channel that is not responsive in presence of TRPML3(D458K). Such a dominant negative action might be attributed to potential heteromerization of TRPML3(D458K) with an SN-2-responsive channel.

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