810668-37-2
810668-37-2 結(jié)構(gòu)式
基本信息
英文別名
RvD2IKFAUGXNBOBQDM-XFMPMKITSA-N
4,8,10,12,14,19-Docosahexaenoic acid, 7,16,17-trihydroxy-, (4Z,7S,8E,10Z,12E,14E,16R,17S,19Z)-
物理化學(xué)性質(zhì)
沸點609.2±55.0 °C(Predicted)
密度1.101±0.06 g/cm3(Predicted)
儲存條件Store at -80°C,protect from light
溶解度DMF: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): .05 mg/ml
酸度系數(shù)(pKa)4.58±0.10(Predicted)
形態(tài)Liquid
顏色Colorless to light yellow
常見問題列表
生物活性
Resolvin D2 是 DHA 的代謝物，具有抗炎和抗感染活性。Resolvin D2 是一種高效的白細胞調(diào)節(jié)器，能控制微生物敗血癥。在原代感覺神經(jīng)元中，Resolvin D2 是 TRPV1 (IC50 = 0.1 nM) 和 TRPA1 (IC50 = 2 nM) 的有效抑制劑。靶點
TRP Channel
體內(nèi)研究
Resolvin D2 induces active resolution of inflammation with pulp-like tissue regeneration after root canal infection and thus maybe suitable for treating periapical lesions.
Resolvin D2 decreases leukocyte:endothelial interactions in vivo by endothelial-dependent nitric oxide production, and direct modulation of leukocyte adhesion receptor expression.
Peripheral administration of Resolvin D2 (10 ng; Intraplantar administration) potently inhibits inflammatory pain.
| Animal Model: | Adult CD1 mice (male, 8–10 weeks) |
| Dosage: | 10 ng |
| Administration: | Intraplantar administration |
| Result: | Inhibited inflammatory pain. |