802555-85-7
中文名稱
P32 INHIBITOR M36 (M36)
英文名稱
p32 Inhibitor M36
CAS
802555-85-7
分子式
C23H28N8O2
分子量
448.52
MOL 文件
802555-85-7.mol
802555-85-7 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
密度1.39±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 5 mg/mL (11.15 mM; ultrasonic and warming and heat to 80°C)
酸度系數(shù)(pKa)13.45±0.46(Predicted)
形態(tài)Solid
顏色White to off-white
常見(jiàn)問(wèn)題列表
生物活性
p32 inhibitor M36 (M36) 是一種 p32 線粒體蛋白小分子抑制劑，可直接與 p32 結(jié)合，抑制 p32 與 LyP-1 的結(jié)合。靶點(diǎn)
p32
體外研究
p32 Inhibitor M36 inhibits SF188 glioma cells proliferation (IC
50
of 77.9 μM in complete media) and is much more potent under low glucose conditions with an IC
50
of 7.3 μM.
p32 Inhibitor M36 is selective for p32 overexpressing cells.
p32 Inhibitor M36 is also a potent inhibitor of patient-derived neurospheres with an IC
50
of 2.8 μM.