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79700-61-1

中文名稱(chēng) 多普吡地
英文名稱(chēng) Dopropidil
CAS 79700-61-1
分子式 C20H35NO2
分子量 321.5
MOL 文件 79700-61-1.mol
79700-61-1 結(jié)構(gòu)式 79700-61-1 結(jié)構(gòu)式

基本信息

中文別名
多普吡地
英文別名
4205CERM
Dopropidil
Pyrrolidine, 1-[1-[(2-methylpropoxy)methyl]-2-[[1-(1-propyn-1-yl)cyclohexyl]oxy]ethyl]-

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
防范說(shuō)明P261-P305+P351+P338

常見(jiàn)問(wèn)題列表

生物活性
Dopropidil 是一種新型的抗心絞痛鈣離子調(diào)節(jié)劑,具有細(xì)胞內(nèi)鈣拮抗劑活性,在動(dòng)物模型中具有抗缺血活性作用。
靶點(diǎn)

Calcium

體外研究

Dopropidil is able to inhibit caffeine-induced contractions of rabbit renal arteries in a calcium-free medium (IC 50 =30.0 uM). Dopropidil inhibits norepinephnne (NE)-induced responses with IC 50 s of 2.7 and 29.8 uM, respectively. At 3 and 10 μM, Dopropidil significantly reduces the maximum increase in diastolic tension evoked by veratrine (IC 50 =2.8 μM).

體內(nèi)研究

Dopropidil (1 and 2.5 mg/kg) dose-dependently reduces the electrical (ST segment elevation), biochemical (lactate production and potassium release), and mechanical (loss in myocardial segment contractility) perturbations induced by ischemia in the anesthetized dog. Intraduodenal administration of Dopropidil (50 mg/kg) significantly reduces isoproterenol-induced tachycardia. This effect is manifest at 15-120 min following administration of the compound which indicates a rapid absorption and a long duration of action. In conscious dogs Dopropidil (12-14 mg/kg p.o.) reduces resting heart rate by approximately10 beats/min.

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