785804-17-3
中文名稱
Abarelix (acetate)
英文名稱
Abarelix (acetate)
CAS
785804-17-3
分子式
C74H99ClN14O16
分子量
1476.14
MOL 文件
785804-17-3.mol
785804-17-3 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 5 mg/ml
形態(tài)結(jié)晶固體
應(yīng)用領(lǐng)域
用途一
Abarelix acetate is a synthetic third generation gonadotropin-releasing hormone receptor (GnRHR) antagonist. It increases histamine release from rat peritoneal mast cells in vitro and from a human skin model ex vivo. In vivo, abarelix decreases plasma luteinizing hormone (LH) levels six hours post-treatment in castrated rats, with levels returning to baseline within 24 hours.3 Abarelix (2 mg/kg) also transiently decreases plasma testosterone levels in intact rats, with levels returning to baseline within seven days post-treatment. Formulations containing abarelix have previously been used in the treatment of advanced prostate cancer.