78499-27-1
78499-27-1 結(jié)構(gòu)式
基本信息
中文別名
化合物 T14546 英文別名
AD-1590Brn 4815717
10,11-DIHYDRO-&alpha
-8-DIMETHYL-11-OXO-DIBENZ(b,f)OXEPIN-2-ACETIC ACID
2-(8-Methyl-10,11-dihydro-11-oxodibenz(B,F)oxepin-2-yl)propionic
10,11-Dihydro-α,8-dimethyl-11-oxodibenz[b,f]oxepine-2-acetic acid
Propionic acid, 2-(8-methyl-10,11-dihydro-11-oxodibenz(B,F)oxepin-2-yl)-
物理化學(xué)性質(zhì)
熔點(diǎn)128-129°
沸點(diǎn)397.92°C (rough estimate)
密度1.1874 (rough estimate)
折射率1.5400 (estimate)
儲(chǔ)存條件-20°C儲(chǔ)存
形態(tài)Solid
顏色Off-white to light yellow
常見問題列表
生物活性
Bermoprofen (AD-1590) 是一種具有口服活性地非甾體類抗炎藥。Bermoprofen 具有有效的解熱和鎮(zhèn)痛作用，且生物半衰期短。Bermoprofen 是 LPS 誘導(dǎo)的兔發(fā)燒的有效拮抗劑。體外研究
Bermoprofen (AD-1590) shows ulcerogenic activity as a side-effect like other nonsteroidal anti-inflammatory agents.
體內(nèi)研究
Bermoprofen (AD-1590) (0.04-0.1 mg/kg; p.o.) shows a dose-related antipyretic activity in LPS-induced febrile rabbits.
| Animal Model: | Male albino rabbits, 2.3-3 kg |
| Dosage: | 0.04, 0.4, 0.1 mg/kg |
| Administration: | Oral; given 1 h after i.v. injection of LPS |
| Result: | Inhibited significantly the rise in rectal temperature at doses of 0.1 mg/kg or more, the temperature returned approximately to normal after 0.4 mg/kg. |