μ-opioid receptor (MOR)

Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHO _hMu , Dermorphin and DeNo displac the binding of [ ³ H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [ ³ H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[ ³⁵ S] in a concentration dependent and saturable manner at the Mu receptor.