77614-16-5
中文名稱
皮啡肽
英文名稱
DERMORPHIN ACETATE
CAS
77614-16-5
分子式
C40H50N8O10
分子量
802.87
MOL 文件
77614-16-5.mol
更新日期
2023/08/08 11:46:17
77614-16-5 結(jié)構(gòu)式
基本信息
中文別名
皮咖肽皮啡肽
醋酸皮啡肽
英文別名
DERMORPHINDermorphin HAc
Dermorphin Powder
DERMORPHIN ACETATE
Dermorphin trifluoroacetate salt
L-Tyr-D-Ala-L-Phe-Gly-L-Tyr-L-Pro-L-Ser-NH2
Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide
(2S)-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenyl-propanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]-N-[(1S)-1-carbamoyl-2-hydro
(2S)-N-[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide
所屬類別
生物化工：多肽物理化學(xué)性質(zhì)
熔點(diǎn)157-159 °C
沸點(diǎn)1323.8±65.0 °C(Predicted)
密度1.363±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)9.83±0.15(Predicted)
形態(tài)粉末
顏色白色至灰白色
序列H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2
InChIKeyFHZPGIUBXYVUOY-VWGYHWLBSA-N
SMILESC(N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N)(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](N)CC1C=CC(O)=CC=1)CC1C=CC=CC=1)CC1C=CC(O)=CC=1
常見(jiàn)問(wèn)題列表
生物活性
Dermorphin 是在兩棲類皮膚中發(fā)現(xiàn)的一種天然七肽 μ-阿片受體 (MOR) 激動(dòng)劑。Dermorphin 可用于抑制神經(jīng)痛。靶點(diǎn)
μ-opioid receptor (MOR)
體外研究
Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHO hMu , Dermorphin and DeNo displac the binding of [ 3 H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [ 3 H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[ 35 S] in a concentration dependent and saturable manner at the Mu receptor.