775351-88-7
中文名稱
3-[3-[(2E)-3,7-二甲基-2,6-辛二烯-1-基]-4-羥基苯基]-7-羥基-4H-1-苯并吡喃-4-酮
英文名稱
3-[3-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-4-hydroxyphenyl]-7-hydroxy-4H-1-benzopyran-4-one
CAS
775351-88-7
分子式
C25H26O4
分子量
390.47
MOL 文件
775351-88-7.mol
更新日期
2024/11/12 10:11:45
775351-88-7 結(jié)構(gòu)式
基本信息
中文別名
次苷酸查爾酮次甘酸查耳酮
補(bǔ)骨脂異黃酮A
化合物CORYLIFOL A
CORYLIFOL A(標(biāo)準(zhǔn)品)
6-辛二烯-1-基]-4-羥基苯基]-7-羥基-4H-1-苯并吡喃-4-酮
3-[3-[(2E)-3,7-二甲基-2,6-辛二烯-1-基]-4-羥基苯基]-7-羥基-4H-1-苯并吡喃-4-酮
英文別名
CorylininCorylifol A
7-Dimethyl-2
3-[3-[(2E)-3
Corylifol A, >99%
CORYLIFOL ACORYLIFOL A
3'-Geranyl-4',7-dihydroxyisoflavone
CORYLIFOL A
3'-GERANYL-4',7-DIHYDROXYISOFLAVONE
CORYLININ
6-octadien-1-yl]-4-hydroxyphenyl]-7-hydroxy-4H-1-benzopyran-4-one
3-[3-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-4-hydroxyphenyl]-7-hydroxy-4H-1-benzopyran-4-one
所屬類別
天然產(chǎn)物：黃酮類化合物物理化學(xué)性質(zhì)
沸點(diǎn)609.3±55.0 °C(Predicted)
密度1.191
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMF:30.0(Max Conc. mg/mL);76.83(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);76.83(Max Conc. mM)
Ethanol:25.0(Max Conc. mg/mL);64.02(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);76.83(Max Conc. mM)
Ethanol:25.0(Max Conc. mg/mL);64.02(Max Conc. mM)
酸度系數(shù)(pKa)6.92±0.20(Predicted)
形態(tài)粉末
顏色偏黃色
InChIInChI=1S/C25H26O4/c1-16(2)5-4-6-17(3)7-8-19-13-18(9-12-23(19)27)22-15-29-24-14-20(26)10-11-21(24)25(22)28/h5,7,9-15,26-27H,4,6,8H2,1-3H3/b17-7+
InChIKeyZBHUUXLHDOUMKM-REZTVBANSA-N
SMILESC1OC2=CC(O)=CC=C2C(=O)C=1C1=CC=C(O)C(C/C=C(\C)/CC/C=C(/C)\C)=C1
常見問(wèn)題列表
生物活性
Corylifol A 能夠抑制IL-6 誘導(dǎo)的 STAT3 的激活和磷酸化，其IC50 值為0.81 μM。靶點(diǎn)
|
STAT3 0.81 μM (IC 50 ) |
體外研究
Corylifol A shows an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC 50 value of 0.81±0.15 μM, also inhibits STAT3 phosphorylation induced by IL-6 in Hep3B cells. Corylifol A inhibits SARA PLpro in a dose-dependent manner with IC 50 s ranging between 4.2 and 38.4 μM. Corylifol A is found to be a naturally occurring potent inhibitor of hCE2, with low K i values ranging from 0.62 μM to 3.89 μM.