771464-86-9
中文名稱(chēng)
普樂(lè)沙福雜質(zhì)G
英文名稱(chēng)
1,11-bis(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzyl)-1,4,8,11-tetraazacyclotetradecane
CAS
771464-86-9
分子式
C46H84N12
分子量
805.24
MOL 文件
771464-86-9.mol
771464-86-9 結(jié)構(gòu)式
基本信息
中文別名
普樂(lè)沙福雜質(zhì)G鹽酸普樂(lè)沙福雜質(zhì)3
英文別名
Plerixafor-3Plerixafor Impurity G
Plerixafor Impurity 23
Plerixafor Impurity III
Plerixafor Impurity 3 HCl
PlerixaforImpurity3Dodecatrifluoroacetate
1,11-Bis[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-cyclotetradecane
Cyclotetradecane, 1,11-bis[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-
1,11-bis(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzyl)-1,4,8,11-tetraazacyclotetradecane
所屬類(lèi)別
有機(jī)原料：羧酸類(lèi)化合物及衍生物應(yīng)用領(lǐng)域
用途一
1,11-Bis(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzyl)-1,4,8,11-tetraazacyclotetradecane is an impurity of Plerixafor (P580500), a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin''s lymphoma (NHL) and multiple myeloma (MM).