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76956-02-0

中文名稱 拉伏替丁
英文名稱 Lavoltidine
CAS 76956-02-0
分子式 C19H29N5O2
分子量 359.47
MOL 文件 76956-02-0.mol
76956-02-0 結(jié)構(gòu)式 76956-02-0 結(jié)構(gòu)式

基本信息

中文別名
拉伏替丁
英文別名
Loxtidina
loxtidine
AH-234844
Lavoltidine
Lavoltidina
Lavoltidinum
Lavoltidine [inn:ban]
Lavoltidinum [inn-latin]
Lavoltidina [inn-spanish]
86160-82-9 (Hemisuccinate[1:1])

常見問題列表

生物活性
Lavoltidine (Loxtidine) 是一種具有口服活性的,不可逆且高效的組胺 H2 受體拮抗劑。Lavoltidine 強烈抑制胃酸分泌,并誘發(fā)高胃泌素血癥。
靶點

H 2 Receptor

體內(nèi)研究

Lavoltidine (Loxtidine; 0.5 g/L; orally (drinking water); changed weekly; for 3 months) shows partial suppression of both gastric acid secretion and progression to neoplasia. Lavoltidine inhibits gastric atrophy, hyperplasia, and dysplasia in H felis -infected INS-GAS mice.
Lavoltidine treatment for 6 months inhibits gastric tumors in H felis -infected INS-GAS mice.

Animal Model: Male hypergastrinemic mice (INS-GAS mice) infected with Helicobacter felis
Dosage: 0.5 g/L
Administration: Orally (drinking water); changed weekly; for 3 months
Result: Showed partial suppression of both gastric acid secretion and progression to neoplasia.
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