75451-07-9
中文名稱
AZ-1355
英文名稱
11,12-dihydro-4-methoxydibenz(b,f)(1,4)oxazepine-8-carboxylate
CAS
75451-07-9
分子式
C17H17NO4
分子量
299.32
MOL 文件
75451-07-9.mol
75451-07-9 結(jié)構(gòu)式
基本信息
中文別名
化合物 T13563 英文別名
AZ-1355
(NSC 36488911,12-dihydro-4-methoxydibenz(b,f)(1,4)oxazepine-8-carboxylate
Dibenz[b,f][1,4]oxazepine-8-carboxylic acid, 10,11-dihydro-4-methoxy-, ethyl ester
常見問題列表
生物活性
AZ-1355 是一種有效的降脂藥，并能夠抑制體內(nèi)血小板凝集，提高體外前列腺素 I2/血栓素A2 的比例。靶點(diǎn)
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Prostaglandin I 2
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Thromboxane A 2
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體內(nèi)研究
AZ-1355 (50 mg/kg) significantly reduces serum TG and the 100 mg/kg dose results in serum TC and TG reduction in rat. AZ-1355 (100 mg/kg) reduces total liver TC in rats fed CE-2, and the 50 mg/kg dose reduces hepatic TC in rats fed the high fat diet on both bases, and it also reduces the total hepatic TG of the CE-2 fed rats. AZ-1355 (150 mg/kg) reproducibly lowers serum total cholesterol (TC) in the Triton hyperlipidemic mice.