749872-43-3
中文名稱
CID 5951923
CAS
749872-43-3
分子式
C16H18N2O7S
分子量
382.39
MOL 文件
749872-43-3.mol
更新日期
2023/03/17 20:03:08
749872-43-3 結(jié)構(gòu)式
基本信息
中文別名
3-(3-硝基苯基)-2-丙烯酸2-[甲基(四氫-1,1-二氧代-3-噻吩基)氨基] -2-氧代乙基酯 英文別名
AC1NZ6UQCID 5951923
KLF5 Inhibitor, CID 5951923
KLF5 Inhibitor, CID 5951923 - CAS 749872-43-3 - Calbiochem
[2-[(1,1-Dioxothiolan-3-yl)-methylamino]-2-oxoethyl] (E)-3-(3-nitrophenyl)prop-2-enoate
2-((1,1-Dioxidotetrahydrothiophen-3-yl)(methyl)amino)-2-oxoethyl 3-(3-nitrophenyl)acrylate
3-(3-Nitro-phenyl)-acrylic acid [(1,1-dioxo-tetrahydro-1l6-thiophen-3-yl)-methyl-carbamoyl]-me
2-[Methyl(tetrahydro-1,1-dioxido-3-thienyl)amino]-2-oxoethyl (E)-3-(3-nitrophenyl)prop-2-enoate
3-(3-Nitrophenyl)-2-propenoic Acid 2-[Methyl(tetrahydro-1,1-dioxido-3-thienyl)aMino]-2-oxoethyl Ester
3-(3-Nitro-phenyl)-acrylic acid [(1,1-dioxo-tetrahydro-1l6-thiophen-3-yl)-methyl-carbamoyl]-methyl ester
常見(jiàn)問(wèn)題列表
生物活性
CID 5951923是一種有效的 Krüppel-like factor 5 (KLF5) 抑制劑，IC50 值為 603 nM，CID 5951923 可在體外抑制癌細(xì)胞的增殖。靶點(diǎn)
IC50: 603 nM (KLF5)
體外研究
CID 5951923 (1 nM-100 μM; 48 h) inhibits proliferation of DLD-1 cells in a dose-dependent manner.
CID 5951923 (10 μM; 24 h) significantly decreases endogenous KLF5 levels in the DLD-1 cells, increases phosphorylation levels of pEGFFpY
1068
, and downregulated EGR1.
CID 5951923 (10 μM) inhibits proliferation of cancer cell lines mainly in highly express KLF5 cells.
Cell Viability Assay
| Cell Line: | DLD-1 and IEC-6 cells |
| Concentration: | 0.001, 0.01, 0.1, 1, 10, 100 μM |
| Incubation Time: | 48 h |
| Result: | Inhibited proliferation of DLD-1 cells with an IC 50 of 1.6 μM. |