74226-22-5
中文名稱
UK-37248
英文名稱
UK-37248
CAS
74226-22-5
分子式
C12H13ClN2O3
分子量
268.696
MOL 文件
74226-22-5.mol
更新日期
2023/03/20 15:41:19
74226-22-5 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
熔點(diǎn)230-235 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7))
儲存條件Inert atmosphere,2-8°C
溶解度DMSO:58.0(Max Conc. mg/mL);215.86(Max Conc. mM)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
Dazoxiben hydrochloride (HCl) 是一種 thromboxane (TX) synthase.的有效，選擇性和口服活性抑制劑。Dazoxiben 可抑制人全血中 TXB2 的產(chǎn)生，其IC50值為0.3 μM，并可平行地增強(qiáng) PGE2 的產(chǎn)生。靶點(diǎn)
| Target | Value |
|
PGE2
() | |
|
TXB2
(Cell-free assay) | 0.3 μM |
體外研究
Dazoxiben inhibits TXB2 production in clotting human whole blood with an IC 50 of 0.3 μM and causes parallel enhancement of PGE2 greater than PGF2 alpha greater than 6-keto-PGF1 alpha production. Dazoxiben inhibits TXB2 production in rat kidney glomeruli with an IC 50 of 1.60 μM) than in rat whole blood (IC 50 = 0.32μM), and is not associated with changes in PGE2, PGF2 alpha and 6-keto-PGF1 alpha production.
體內(nèi)研究
Dazoxiben (intraperitoneal administration; 100 μg/kg) produces a marked prolongation of the tail bleeding time with 96.8 ± 10.8 secs.