73634-68-1
中文名稱
(D-TRP11)-NEUROTENSIN
英文名稱
PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-D-TRP-ILE-LEU-OH
CAS
73634-68-1
分子式
C80H122N22O19
分子量
1695.96
MOL 文件
73634-68-1.mol
73634-68-1 結(jié)構(gòu)式
基本信息
英文別名
PYR-LYENKPRRPWIL[D-TRP11]-NEUROTENSIN
GLP-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-DTRP-ILE-LEU
PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-D-TRP-ILE-LEU
pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-D-Trp-Ile-Leu
PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-D-TRP-ILE-LEU-OH
pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-D-Trp-Ile-Leu-OH
常見(jiàn)問(wèn)題列表
生物活性
[D-Trp11]-Neurotensin 是 Neurotensin (NT) 的類(lèi)似物,在灌注的大鼠心臟中是 NT 的選擇性拮抗劑,但在豚鼠心房和大鼠胃條中起完全激動(dòng)劑的作用。[D-Trp11]-Neurotensin 可抑制 NT 引起的低血壓。靶點(diǎn)
Neurotensin Receptor
體外研究
[D-Trp11]-Neurotensin (0.13-1.1 μM) markedly inhibits NT-induced coronary vessel constriction in perfused rat hearts.
[D-Trp11]-Neurotensin (2-110 μM) exhibits NT-like activity in perfused rat hearts.
體內(nèi)研究
[D-Trp11]-Neurotensin (50-500 nmol/kg; i.v.) has hypotensive activity in pentobarbital-anesthetized rats, with an ED 25 of 122 nmol/kg.