732973-87-4
中文名稱
N-(4-氯苯基)-4-(1H-吲哚-4-基)哌嗪-1-甲酰胺
英文名稱
GOT1 inhibitor 2c
CAS
732973-87-4
分子式
C19H19ClN4O
分子量
354.83
MOL 文件
732973-87-4.mol
更新日期
2024/12/23 09:08:09
732973-87-4 結(jié)構(gòu)式
基本信息
中文別名
化合物GOT1 INHIBITOR-1N-(4-氯苯基)-4-(1H-吲哚-4-基)哌嗪-1-甲酰胺
英文別名
GOT1 inhibitor-1GOT1 inhibitor 2c
N-(4-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
GOT1 inhibitor1,inhibit,GOT-1 inhibitor-1,glutamate-oxaloacetate transaminase 1,Cancer,Pancreatic,GOT1,metabolism,?Aspartate aminotransferase-1,ductal,Inhibitor,GOT1 inhibitor 1,PDAC,adenocarcinoma,GOT1 inhibitor-1
物理化學(xué)性質(zhì)
沸點(diǎn)639.5±55.0 °C(Predicted)
密度1.387±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 125 mg/mL (352.28 mM)
酸度系數(shù)(pKa)13.07±0.70(Predicted)
形態(tài)Solid
顏色Off-white to light yellow
水溶解性Water: < 0.1 mg/mL (insoluble)
常見(jiàn)問(wèn)題列表
生物活性
GOT1 inhibitor-1 (compound 2c) 是一種戊酸衍生物，是一種新型的、有效的、非共價(jià)的谷氨酸草酰乙酸轉(zhuǎn)氨酶 1 (GOT1) 抑制劑，IC50 為 8.2 uM。 GOT1 inhibitor-1 可用于胰腺導(dǎo)管腺癌 (PDAC) 的研究。體外研究
PDAC tumors are dependent upon a metabolic pathway involving aspartate aminotransferase 1 (glutamate-oxaloacetate transaminase 1 (GOT1)), for the maintenance of redox homeostasis and sustained proliferation. Small molecule inhibitors targeting this metabolic pathway may provide a novel way for cancer research. In the MDH coupled GOT1 enzymatic assay, GOT1 inhibitor-1 shows an inhibitory effect on GOT1 activity with an IC 50 value of 8.2 uM.