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72814-32-5

中文名稱 BW 245C
英文名稱 BW 245C
CAS 72814-32-5
分子式 C19H32N2O5
分子量 368.47
MOL 文件 72814-32-5.mol
更新日期 2024/12/03 15:40:35
72814-32-5 結(jié)構(gòu)式 72814-32-5 結(jié)構(gòu)式

基本信息

中文別名
化合物 T14842
英文別名
BW 245C
3-(3-Cyclohexyl-3-hydroxypropyl)-2,5-dioxo-(R*,S*)-(±)-4-imidazolineheptanioc acid
3-(3-CYCLOHEXYL-3-HYDROXYPROPYL)-2,5-DIOXO-(R*,S*)-(+/-)-4-IMIDAZOLINEHEPTANOIC ACID
(4S)-(3-[(3R,S)-3-CYCLOHEXYL-3-HYDROXYPROPYL]-2,5-DIOXO)-4-IMIDAZOLIDINE-HEPTANOIC ACID
4-Imidazolidineheptanoic acid, 3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxo-, (R*,S*)-( -)-
4-Imidazolidineheptanoic acid, 3-[(3S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo-, (4R)-rel-
4-Imidazolidineheptanoic acid, 3-((3R)-3-cyclohexyl-3-hydroxypropyl)-2,5-dioxo-, (4S)-rel-

物理化學(xué)性質(zhì)

密度1.167±0.06 g/cm3(Predicted)
儲存條件−20°C
溶解度DMSO: 30 mg/mL, soluble
酸度系數(shù)(pKa)4.77±0.10(Predicted)
形態(tài)solid
顏色off-white

安全數(shù)據(jù)

危險(xiǎn)性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
WGK Germany3
BW 245C價格(試劑級)
報(bào)價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-101987BW 245C
BW 245C
72814-32-51mg1400元
2024/11/08HY-101987BW 245C
BW 245C
72814-32-510 mM * 1 mLin DMSO2432元
2024/11/08HY-101987BW 245C
BW 245C
72814-32-55mg3000元

常見問題列表

生物活性
BW 245C 是一種有效的前列腺素類DP受體prostanoid DP-receptor (DP1)激動劑,常用于中風(fēng)等疾病的研究。
靶點(diǎn)

DP/DP1 Receptor

體外研究

BW245C (0.01-1 μM) suppresses TGF-β-induced collagen secretion in a dose-dependent manner in Th2 cells. BW245C (0.01-1 μM) also increases intracellular cAMP in lung fibroblasts. BW245C (0.1-3 μmol/L) dose-dependently increases transendothelial electrical resistance and decreases the FITC-dextran permeability of human umbilical vein endothelial cells. BW245C (0.3 μmol/L) increases the intracellular cAMP level and subsequent protein kinase A (PKA) activity.

體內(nèi)研究

BW245C (0.02, 0.2, and 2.0 mg/kg) in WT mice results in a significant increase in CBF, but this effect of this treatment is absent in DP1 ?/? mice. BW245C attenuates functional deficits after stroke. BW245C significantly reverses these conditions that neurologic deficit is significantly augmented, whereas locomotor activity is significantly reduced after stroke in WT mice. BW245C (0.2 mg/kg) injection 1 h after stroke results in a significant decrease in brain infarction in WT mice, whereas the effect of this treatment is not observed in DP1 ?/? mice. BW245C improves CBF during and after stroke. BW245C results in significantly prolonged bleeding compared with the vehicle-treated group. BW 245C (100 nM) does not significantly increase MBP-positive eosinophils in esophageal epithelium in OVA-sensitized guinea pigs.

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