72124-77-7
72124-77-7 結(jié)構(gòu)式
基本信息
中文別名
CALIMYCIN 半鎂鹽 英文別名
Calcimycin hemimagnesiuma23187hemimagnesium salt
CALCIMYCIN HEMIMAGNESIUM SALT
CALCIMYCIN A23187 HEMIMAGNESIUM SALT
calcium ionophore A23187 hemimagnesium
CALCIUM IONOPHORE A23187 HEMIMAGNESIUM SALT
CALCIUM IONOPHORE A23187 HEMIMAGNESIUM SALT BIOCHEMIKA
A23187 hemimagnesium salt, Antibiotic A 23187 hemimagnesium salt, Calcimycin hemimagnesium salt, Calimycin hemimagnesium salt
CALIMYCIN 半鎂鹽價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2023/03/20 | HY-N6687B | CALIMYCIN 半鎂鹽 Calcimycin hemimagnesium | 72124-77-7 | 1mg | 2600元 |
| 2023/03/20 | HY-N6687B | CALIMYCIN 半鎂鹽 Calcimycin hemimagnesium | 72124-77-7 | 5mg | 7200元 |
常見問題列表
生物活性
Calcimycin (A-23187) hemimagnesium 是一種抗生素和獨(dú)特的二價陽離子離子載體 (divalent cation ionophore)，如鈣離子和鎂離子。Calcimycin hemimagnesium 通過增加細(xì)胞內(nèi)鈣濃度誘導(dǎo) Ca2+ 依賴性細(xì)胞死亡。Calcimycin hemimagnesium 抑制革蘭氏陽性細(xì)菌和一些真菌的生長，還抑制 ATP 酶的活性并解耦哺乳動物細(xì)胞的氧化磷酸化 (OXPHOS)，誘導(dǎo)細(xì)胞凋亡 (apoptosis)。體外研究
Calcimycin (A-23187) hemimagnesium mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner.
體內(nèi)研究
Calcimycin (A-23187) hemimagnesium (2.5 or 7.5 nM; intrapleurally) induces protein leakage.
| Animal Model: | Mice (ICR, 25-30 g) |
| Dosage: | 2.5 or 7.5 nM |
| Administration: | Intrapleurally |
| Result: | Two hours after 2.5 nM, or three hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values. |