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71861-76-2

中文名稱(chēng) 1-acetyl-3,2-toluyl-5-fluorouracil
英文名稱(chēng) 1-acetyl-3,2-toluyl-5-fluorouracil
CAS 71861-76-2
分子式 C14H11FN2O4
分子量 290.25
MOL 文件 71861-76-2.mol
71861-76-2 結(jié)構(gòu)式 71861-76-2 結(jié)構(gòu)式

基本信息

中文別名
化合物 T10013
英文別名
A-?OT-?Fu
1-Acetyl-3-o-toluyl-5-fluorouracil
1-acetyl-3,2-toluyl-5-fluorouracil
2,4(1H,3H)-Pyrimidinedione, 1-acetyl-5-fluoro-3-(2-methylbenzoyl)-

物理化學(xué)性質(zhì)

熔點(diǎn)141-143 °C(Solv: ethyl ether (60-29-7))
沸點(diǎn)408.8±55.0 °C(Predicted)
密度1.44±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)-5.29±0.40(Predicted)

常見(jiàn)問(wèn)題列表

生物活性
1-Acetyl-3-o-toluyl-5-fluorouracil是有效的抗腫瘤劑。
體內(nèi)研究

Oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil demonstrates a remarkable effect on MH134 solid tumors, the effect being more marked than that of subcutaneous administration of 1-Acetyl-3-o-toluyl-5-fluorouracil. Anti-tumor activity of oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at a dose of 0.2 mmol/kg/d is comparable to that of subcutaneous administration of 5-fluorouracil at the same dose. The level of decrease in thymus weight and the magnitude of increase of spleen weight following oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at any dose are smaller than those by subcutaneous administration of 5-fluorouracil (0.2 mmol/kg/d).

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