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71678-03-0

中文名稱 3-[(十氫-1Β,2Β,4AΒ-三甲基-5-亞甲基-1-萘基)甲基]-2-羥基-5-甲氧基苯醌
英文名稱 ILIMAQUINONE
CAS 71678-03-0
分子式 C22H30O4
分子量 358.47
MOL 文件 71678-03-0.mol
71678-03-0 結構式 71678-03-0 結構式

基本信息

中文別名
3-[(十氫-1Β,2Β,4AΒ-三甲基-5-亞甲基-1-萘基)甲基]-2-羥基-5-甲氧基苯醌
英文別名
IQ
ILIMAQUINONE
illimaquinone
(-)-Ilimaquinine
(-)-ILIMAQUINONE
5-Epiilimaquinone
Ilimaquinone - CAS 71678-03-0 - Calbiochem
3-[(decahydro-1β,2β,4aβ-trimethyl-5-methylene-1-naphthyl)methyl]-2-hydroxy-5-methoxybenzoquinone
3-[(DECAHYDRO-1B,2B,4AB-TRIMETHYL-5-METHYLENE-1-NAPHTHYL)METHYL]-2-HYDROXY-5-METHOXYBENZOQUINONE
2-[[(1R,8aα)-1,2β,4aβ-Trimethyl-5-methylenedecalin-1α-yl]methyl]-3-hydroxy-6-methoxy-1,4-benzoquinone

物理化學性質

熔點108-110℃ (pentane )
比旋光度D23 -23.2° (c = 1.12 in CHCl3)
沸點478.4±45.0 °C(Predicted)
密度1.14±0.1 g/cm3(Predicted)
儲存條件−20°C
溶解度DMSO: Soluble; Ethanol: Soluble; Hexane: Soluble; Methanol: Soluble
酸度系數(shù)(pKa)2.92±0.50(Predicted)
形態(tài)紅色固體
顏色Light yellow to brown

安全數(shù)據(jù)

WGK Germany3

常見問題列表

生物活性
Ilimaquinone 是一種海洋海綿狀代謝產(chǎn)物,通過 GADD153 介導的信號通路發(fā)揮抗腫瘤活性。Ilimaquinone 可以誘導高爾基體的囊泡化。Ilimaquinone 具有抗病毒,抗菌和抗炎活性。
體外研究

Ilimaquinone induces a concentration-dependent anti-proliferative effect in several types of cancer cell lines, including prostate cancer PC-3 and LNCaP, non-small cell lung cancer A549 and hepatocellular carcinoma Hep3B cells. Ilimaquinone (0.3-30 μM ; 48 hours) inhibits the proliferation of PC-3 cells, DU145, LNCaP, MG63, A549, Hep3B cells with GI 50 s of 2.6 μM, 5.8, 4.6, 4.9, 4.1, 12.0μM, respectively.

Cell Viability Assay

Cell Line: Prostate cancer PC-3 cells
Concentration: 0.3, 1, 3, 10, and 30 μM
Incubation Time: 48 hours
Result: Inhibited the proliferation of PC-3 cells in a concentration-dependent manner.
體內研究

Ilimaquinone exhibits terminal elimination half-lives (T 1/2 =1.2±0.3 h) due to high plasma clearance (2.95±0.53 L/h/kg) following oral administration (10 mg/kg) in male Sprague-Dawley rats.

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