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70052-12-9

中文名稱 消旋型二氟甲基腈鹽酸鹽
英文名稱 DFMO
CAS 70052-12-9
分子式 C6H12F2N2O2
分子量 182.17
MOL 文件 70052-12-9.mol
更新日期 2024/07/08 16:38:19
70052-12-9 結(jié)構(gòu)式 70052-12-9 結(jié)構(gòu)式

基本信息

中文別名
依氟烏氨酸
依氟鳥氨酸堿
二氟甲基鳥氨酸
依氟鳥氨酸堿鹽酸鹽
依氟鳥氨酸堿(消旋體)
消旋型二氟甲基腈鹽酸鹽
DL-Α-二氟甲基鳥氨酸鹽酸鹽
DL-ALPHA-二氟甲基鳥氨酸鹽酸鹽
英文別名
DFMO
RFI 71782
Ccris 3295
Brn 2250529
EFLORNITINE
DL-EFLORNITHINE
H-DL-(F2ME)ORN-OH
DIFLUOROMETHYLORNITHINE
α-Difluoromethylornitine
DFMO hydrochloride hydrate
所屬類別
有機(jī)原料:羧酸類化合物及衍生物

物理化學(xué)性質(zhì)

熔點(diǎn)138 °C
沸點(diǎn)347.0±42.0 °C(Predicted)
密度1.1800 (estimate)
儲(chǔ)存條件Store at 0°C
溶解度H2O: >10 mg/mL, soluble
酸度系數(shù)(pKa)1.22±0.44(Predicted)
形態(tài)solid
顏色white

安全數(shù)據(jù)

WGK Germany3
毒害物質(zhì)數(shù)據(jù)70052-12-9(Hazardous Substances Data)

常見問題列表

生物活性
Eflornithine (DFMO) 是酶鳥氨酸脫羧酶的特異性不可逆抑制劑。Eflornithine 可用于研究非洲錐蟲病和女性面部毛發(fā)過度生長(zhǎng)。
體內(nèi)研究

Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension.

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