69207-52-9
中文名稱
methyl 2-tetradecylglycidate
英文名稱
methyl 2-tetradecylglycidate
CAS
69207-52-9
分子式
C18H34O3
分子量
298.46
MOL 文件
69207-52-9.mol
69207-52-9 結構式
基本信息
中文別名
帕莫酸甲酯 英文別名
MCN-3716NSC359682)
Methyl parmoxirate
Methyl palmoxirate
McN3716 (Methyl palmoxirate
methyl 2-tetradecylglycidate
2-Tetradecyloxiranecarboxylic acid methyl ester
2-Tetradecyloxirane-2-carboxylic acid methyl ester
物理化學性質(zhì)
熔點44-46 °C
沸點361.4±17.0 °C(Predicted)
密度0.944±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
形態(tài)Solid
顏色White to off-white
methyl 2-tetradecylglycidate價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-U00159 | methyl 2-tetradecylglycidate McN3716 | 69207-52-9 | 1 mg | 3950元 |
常見問題列表
生物活性
McN3716 是一種肉堿棕櫚酰轉(zhuǎn)移酶 I (CPT-1) 抑制劑。靶點
Carnitine palmitoyltransferase I (CPT-1)
體內(nèi)研究
Inhibition of brain mitochondrial β-oxidation by McN3716 (Methyl palmoxirate, MEP) significantly reduces the levels of all measured HETE and epoxytrienoic acids (EET), nonenzymatic auto-oxidative metabolites of ARA, by 23% to 44% and 32% to 50% compared with vehicle-injected rats, respectively, except for 15-HETE which was unaffected. There is a significant 34% reduction in the level of 6-keto-PGF 1α , a byproduct of PGI 2 (prostacyclin) in McN3716-treated rats. Similarly, the brain level of hydroxyeicosapentaenoic acids, nonenzymatic auto-oxidative metabolites of EPA, is reduced by 35% to 76% upon McN3716 treatment relative to vehicle.