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691392-89-9

英文名稱(chēng) MS0022
CAS 691392-89-9
分子式 C21H16BrN3O
分子量 406.28
MOL 文件 691392-89-9.mol
691392-89-9 結(jié)構(gòu)式 691392-89-9 結(jié)構(gòu)式

基本信息

英文別名
MS0022

應(yīng)用領(lǐng)域

用途一
MS-0022 is a SMO antagonist. MS-0022 showed effective Hh signaling pathway inhibition at the level of SMO in the low nM range, and Hh pathway inhibition downstream of Suppressor of fused (SUFU) in the low μM range. MS-0022 reduced growth in the tumor cell lines PANC-1, SUIT-2, PC-3 and FEMX in vitro. MS-0022 is a treatment led to a transient delay of tumor growth that correlated with a reduction of stromal Gli1 levels in SUIT-2 xenografts in vivo.
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