68060-49-1
中文名稱
ARG-PRO-LYS-PRO-GLN-GLN-PHE
英文名稱
SUBSTANCE P (1-7)
CAS
68060-49-1
分子式
C41H65N13O10
分子量
900.04
MOL 文件
68060-49-1.mol
更新日期
2024/12/17 14:15:59
68060-49-1 結(jié)構(gòu)式
基本信息
中文別名
1-7-P 物質(zhì) 英文別名
RPKPQQF1-7-Substance P
SUBSTANCE P (1-7)
SUBSTANCE P FRAGMENT 1-7
ARG-PRO-LYS-PRO-GLN-GLN-PHE
H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-OH
SUBSTANCE P FRAGMENT 1-7SUBSTANCE
Substance P Fragment 1-7, ≥97% (HPLC)
L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-OH
L-Arg-L-Pro-L-Lys-L-Pro-L-Glu(NH2)-L-Glu(NH2)-L-Phe-OH
物理化學(xué)性質(zhì)
密度1.49±0.1 g/cm3(Predicted)
儲(chǔ)存條件−20°C
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)3.49±0.10(Predicted)
常見問題列表
生物活性
Substance P(1-7) 是神經(jīng)肽P物質(zhì) (SP) 的片段。Substance P(1-7) 可對(duì)孤束核產(chǎn)生抑制和緩和作用。體內(nèi)研究
Substance P (1-7) is found to act as a very potent antagonist against the SP-induced responses and is formed locally in the nigra after SP injection. It is proposed that Substance P (1-7) is an endogenous modulator of SP actions. Injection of low doses of Substance P (1-7) (1.0-4.0 pM simultaneously with SP or SP(5-11) (0.1 nM), reduce aversive behaviours induced by SP or SP(5- 11) significantly. These results indicate that SP(1-7) formed endogenously could modulate the actions of SP or SP(5-11) in the spinal cord.