67684-64-4
基本信息
Trans-(±)-ACP
TRANS-(±)-ACPD
TRANS-(+/-)-ACPD
(+/-)-TRANS-ACPD
trans-(±)-ACPD monohydrate
TRANS(+-)-ACPD EXCITATORY AMINO ACID
TRANS-(+/-)-1-AMINO-1,3-CYCLOPENTANEDICARBOXYLIC ACID
(+/-)-1-AMINOCYCLOPENTANE-TRANS-1,3-DICARBOXYLIC ACID
(+/-)-1-Aminocyclopentanl-trans-1,3-Dicarboxylic acid
物理化學(xué)性質(zhì)
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
2024/11/08 | HY-19434 | (±)-TRANS-ACPD trans-ACPD | 67684-64-4 | 10mM * 1mLin DMSO | 726元 |
2024/11/08 | HY-19434 | (±)-TRANS-ACPD trans-ACPD | 67684-64-4 | 5mg | 830元 |
2024/11/08 | HY-19434 | (±)-TRANS-ACPD trans-ACPD | 67684-64-4 | 10mg | 1304元 |
常見問題列表
mGluR
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Excitatory amino acid (EAA) analogues activate receptors that are coupled to the increased hydrolysis of phosphoinositides (PIs). In these studies, hippocampal slices are prepared from neonatal rats (6-11 days old) to characterize the effects of EAA analogues on these receptors. The concentrations of trans-ACPD required to evoke half-maximal stimulation (EC 50 value) is 51 μM. DL-2-Amino-3-phosphonopropionate (DL-AP3) is also equipotent as an inhibitor of PI hydrolysis stimulated by ibotenate, quisqualate, and trans-ACPD (IC 50 values are 480-850 μM).
Intrathecal injection of NMDA, kainate, and trans-ACPD, TNF-α, or IL-1β causes significant (p<0.001) biting behaviour in mice compared to animals injected intrathecally with saline. In all groups, systemic pre-treatment with GM (100 mg/kg, i.p.) significantly (p<0.001) reduces the biting behaviour compared to mice treated with saline (10 mL/kg, i.p.). The greatest effect of GM is observed on the pro-inflammatory cytokines and NMDA, with the following inhibition percentages: TNF-α (92±7%), IL-1β (91±5%), NMDA (69±1%), and trans-ACPD (71±12%). By contrast, at the same dose, GM has no significant effect on the kainate-mediated biting response.