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67684-64-4

中文名稱 (±)-TRANS-ACPD
英文名稱 (+/-)-1-AMINOCYCLOPENTANE-TRANS-1,3-DICARBOXYLIC ACID
CAS 67684-64-4
分子式 C7H11NO4
分子量 173.17
MOL 文件 67684-64-4.mol
67684-64-4 結(jié)構(gòu)式 67684-64-4 結(jié)構(gòu)式

基本信息

中文別名
化合物(±)-TRANS-ACPD
英文別名
TRANS-ACPD
Trans-(±)-ACP
TRANS-(±)-ACPD
TRANS-(+/-)-ACPD
(+/-)-TRANS-ACPD
trans-(±)-ACPD monohydrate
TRANS(+-)-ACPD EXCITATORY AMINO ACID
TRANS-(+/-)-1-AMINO-1,3-CYCLOPENTANEDICARBOXYLIC ACID
(+/-)-1-AMINOCYCLOPENTANE-TRANS-1,3-DICARBOXYLIC ACID
(+/-)-1-Aminocyclopentanl-trans-1,3-Dicarboxylic acid

物理化學(xué)性質(zhì)

沸點(diǎn)352.7±42.0 °C(Predicted)
密度1.452±0.06 g/cm3(Predicted)
儲(chǔ)存條件Keep in dark place,Inert atmosphere,2-8°C
溶解度水中的溶解度為1mg/mL
酸度系數(shù)(pKa)2.11±0.40(Predicted)
形態(tài)固體
顏色白色
水溶解性Soluble to 5 mM in water with gentle warming and to 50 mM in 1eq. NaOH

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302+H312+H332
危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類別碼20/21/22
WGK Germany3
(±)-TRANS-ACPD價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-19434(±)-TRANS-ACPD
trans-ACPD
67684-64-410mM * 1mLin DMSO726元
2024/11/08HY-19434(±)-TRANS-ACPD
trans-ACPD
67684-64-45mg830元
2024/11/08HY-19434(±)-TRANS-ACPD
trans-ACPD
67684-64-410mg1304元

常見問題列表

生物活性
trans-ACPD 是一種代謝型受體激動(dòng)劑,促進(jìn)鈣離子活動(dòng)及產(chǎn)生內(nèi)向電流。
靶點(diǎn)

mGluR

體外研究

Excitatory amino acid (EAA) analogues activate receptors that are coupled to the increased hydrolysis of phosphoinositides (PIs). In these studies, hippocampal slices are prepared from neonatal rats (6-11 days old) to characterize the effects of EAA analogues on these receptors. The concentrations of trans-ACPD required to evoke half-maximal stimulation (EC 50 value) is 51 μM. DL-2-Amino-3-phosphonopropionate (DL-AP3) is also equipotent as an inhibitor of PI hydrolysis stimulated by ibotenate, quisqualate, and trans-ACPD (IC 50 values are 480-850 μM).

體內(nèi)研究

Intrathecal injection of NMDA, kainate, and trans-ACPD, TNF-α, or IL-1β causes significant (p<0.001) biting behaviour in mice compared to animals injected intrathecally with saline. In all groups, systemic pre-treatment with GM (100 mg/kg, i.p.) significantly (p<0.001) reduces the biting behaviour compared to mice treated with saline (10 mL/kg, i.p.). The greatest effect of GM is observed on the pro-inflammatory cytokines and NMDA, with the following inhibition percentages: TNF-α (92±7%), IL-1β (91±5%), NMDA (69±1%), and trans-ACPD (71±12%). By contrast, at the same dose, GM has no significant effect on the kainate-mediated biting response.

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