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67401-56-3

中文名稱 MICROCOCCIN P1
英文名稱 13',19'-Didehydro-19'-deoxy-28,44-dihydro-44-hydroxymicrococcin P
CAS 67401-56-3
分子式 C48H49N13O9S6
分子量 1144.37
MOL 文件 67401-56-3.mol
更新日期 2023/03/20 15:41:19
67401-56-3 結(jié)構(gòu)式 67401-56-3 結(jié)構(gòu)式

基本信息

中文別名
微球菌素P1
英文別名
Brn 1070340
Micrococcin P1
MQGFYNRGFWXAKA-QMXXNAFJSA-N
13',19'-Didehydro-19'-deoxy-28,44-dihydro-44-hydroxymicrococcin P
Micrococcin p, 13',19'-didehydro-19'-deoxy-28,44-dihydro-44-hydroxy-
[2,4'-Bithiazole]-4-carboxamide, 2'-[(11S,14Z,21S,28S)-14-ethylidene-9,10,11,12,13,14,20,21,27,28-decahydro-28-[(1R)-1-hydroxyethyl]-11-[(1R)-1-hydroxyethyl]-21-(1-methylethyl)-9,12,19,26-tetraoxo-19H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazac...

物理化學(xué)性質(zhì)

密度1.1650 (rough estimate)
折射率1.6700 (estimate)
儲存條件-20°C儲存
溶解度DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
酸度系數(shù)(pKa)10.68±0.46(Predicted)
形態(tài)固體
顏色White to yellow
MICROCOCCIN P1價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-125728MICROCOCCIN P1
Micrococcin P1
67401-56-3500μg6400元
2023/03/20HY-125728MICROCOCCIN P1
Micrococcin P1
67401-56-31mg15500元

常見問題列表

生物活性
Micrococcin P1 是一種大環(huán)肽抗生素,是一種有效的丙型肝炎病毒 (HCV) 抑制劑,EC50 范圍為 0.1-0.5 μM。Micrococcin P1 對革蘭氏陽性細(xì)菌菌株具有體外抗菌活性,對金黃色葡萄球菌 1974149 菌株,糞腸球菌 1674621 菌株和化膿性鏈球菌 1744264 菌株的 MIC 值分別為 2 μg/ mL,1 μg/ mL 和 1 μg/ mL。Micrococcin P1 還是瘧疾寄生蟲惡性瘧原蟲的有效抑制劑。
靶點

HCV; Bacterial; Parasite

體外研究

Dose-response assays reveales Micrococcin P1 to be very potent with a minimal inhibitory concentration (MIC) of 32-63 nM. Cytotoxicity assays reveales no significant impairment on cell line growth (<10% inhibition at 30 mM) over a 40 h period for both the hepatic cell line HepG2 and the monocytic cell line THP-1, leading to a selectivity index greater than 500. Also investigats the intracellular activity of Micrococcin P1, it is active against GFP-expressing M. tuberculosis H37Rv growing inside RAW 264.7 macrophages with an IC 80 of about 1 mM with potency comparable with that of isoniazid.

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