673202-67-0
中文名稱(chēng)
673202-67-0
英文名稱(chēng)
FURIN INHIBITOR II
CAS
673202-67-0
分子式
C36H75N25O6
分子量
954.14
MOL 文件
673202-67-0.mol
更新日期
2024/12/16 11:45:49
673202-67-0 結(jié)構(gòu)式
基本信息
中文別名
D型六聚精氨酸六-D-精氨酸
六-D-精氨酸, >98%
化合物HEXA-D-ARGININE
(R)-2-氨基-N-((6R,9R,12R,15R,18R)-1,23-二氨基-6-氨基甲?；?9,12,15-三(3-胍基丙基)-1,23-二亞氨基-8,11,14,17-四氧代-2,7,10,13,16,22-六氮雜二十三烷-18-基)-5-胍基戊酰胺
英文別名
H-(D)RRRRRR-NH2HEXA-D-ARGININE
FURIN INHIBITOR II
Hexa-D-arginine aMide
Hexa-D-arginine,RRRRRR
Furin Inhibitor II, >98%
H-D-ARG-D-ARG-D-ARG-D-ARG-D-ARG-D-ARG-NH2
D-Argininamide,D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-
D-Argininamide, D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl- (9CI)
D-ArgininamideD-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-alanine
物理化學(xué)性質(zhì)
密度1.59±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C
儲(chǔ)存條件Keep in dark place,Sealed in dry,Store in freezer, under -20°C
溶解度H2O : 50 mg/mL (52.40 mM; Need ultrasonic)DMSO : 5 mg/mL (5.24 mM; Need ultrasonic)
酸度系數(shù)(pKa)13.24±0.46(Predicted)
形態(tài)lyophilized
顏色White to off-white
水溶解性Soluble to 2 mg/ml in water
673202-67-0價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-P1028 | 673202-67-0 Hexa-D-arginine | 673202-67-0 | 1mg | 600元 |
| 2024/11/08 | HY-P1028 | 673202-67-0 Hexa-D-arginine | 673202-67-0 | 5mg | 1700元 |
| 2024/11/08 | HY-P1028 | 673202-67-0 Hexa-D-arginine | 673202-67-0 | 10mg | 2720元 |
常見(jiàn)問(wèn)題列表
生物活性
Hexa-D-arginine (Furin Inhibitor II) 是一種穩(wěn)定的 furin 抑制劑，對(duì) furin，PACE4 和 PC1 的 Ki 值分別為 106 nM，580 nM 和 13.2 μM。Hexa-D-arginine 在體外和體內(nèi)均可阻斷假單胞菌外毒素 A 和炭疽毒素的毒性。靶點(diǎn)
Ki: 106 nM (Furin), 580 nM (PACE4) and 13.2 μM (PC1)
體外研究
Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic.
體內(nèi)研究
Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α.