664993-53-7
中文名稱
JW-55
英文名稱
JW55
CAS
664993-53-7
分子式
C25H26N2O5
分子量
434.48
MOL 文件
664993-53-7.mol
更新日期
2024/12/23 09:08:10
664993-53-7 結(jié)構(gòu)式
基本信息
中文別名
Β-CATENIN抑制劑(JW 55)N-(4-((4-(4-甲氧基苯基)四氫-2H-吡喃-4-基)甲基氨基甲?；?苯基)呋喃-2-甲酰胺
N-[4-[[[[四氫-4-(4-甲氧基苯基)-2H-吡喃-4-基]甲基]氨基]羰基]苯基]-2-呋喃甲酰胺
N-[4-[[[[四氫-4-(4-甲氧基苯基)-2H-吡喃-4-基]甲基]氨基]羰基]苯基]-2-呋喃甲酰胺(JW55)
英文別名
JW55CS-1095
JW 55
JW-55
JW 55, >=98%
Tankyrase1/2 Inhibitor IV, JW55
Tankyrase1/2 Inhibitor IV, JW55 - CAS 664993-53-7 - Calbiochem
N-[4-[[4-(4-METHOXYPHENYL)OXAN-4-YL]METHYLCARBAMOYL]PHENYL]FURAN-2-CARBOXAMIDE
N-(4-((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)MethylcarbaMoyl)phenyl)furan-2-carboxaMide
N-(4-(((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamid
N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)572.6±50.0 °C(Predicted)
密度1.235±0.06 g/cm3(Predicted)
儲(chǔ)存條件Inert atmosphere,2-8°C
溶解度DMSO：可溶15mg/mL，澄清
酸度系數(shù)(pKa)12.41±0.70(Predicted)
形態(tài)粉末
顏色白色至米色
常見(jiàn)問(wèn)題列表
生物活性
JW55是一種有效的、選擇性經(jīng)典Wnt信號(hào)通路抑制劑，通過(guò)抑制TNKS1/2的PARP區(qū)域發(fā)揮作用。靶點(diǎn)
| Target | Value |
|
Wnt
() |
體外研究
JW 55 (JW55) is a potent and selective inhibitor of the canonical Wnt pathway. Wnt3a-induced HEK293 cells containing a transiently transfected ST-Luc (SuperTop-luciferase) reporter show inhibition by JW55 with an IC 50 value of 470 nM. JW55 is effective in the range of 1 to 5 μM in SW480 cells and 0.01 to 5 μM in HCT-15 cells. JW55 is effective in the range of 1 to 5 μM in SW480 cells and 0.01 to 5 μM in HCT-15 cells.
體內(nèi)研究
JW 55 (100 mg/kg, orally) reduces tumor development in conditional Apc knockout mice. JW55 reduces XWnt8-induced axis duplication in Xenopus embryos and Tamoxifen-induced polyposis formation in conditional APC mutant mice.