638156-11-3
中文名稱
CID-2011756
英文名稱
CID-2011756,5-(3-chlorophenyl)-N-(4-(MorpholinoMethyl)phenyl)furan-2-carboxaMide
CAS
638156-11-3
分子式
C22H21ClN2O3
分子量
396.87
MOL 文件
638156-11-3.mol
更新日期
2024/12/15 19:35:15
638156-11-3 結(jié)構(gòu)式
基本信息
中文別名
PKD1抑制劑(CID 2011756)5-(3-氯苯基)-N-(4-(嗎啉甲基)苯基)呋喃-2-羧酰胺
5-(3-氯苯基)-N-[4-(4-嗎啉基甲基)苯基]-2-呋喃甲酰胺
5-(3-氯苯基)-N-[4-(4-嗎啉基甲基)苯基]-2-呋喃甲酰胺(CID-2011756)
英文別名
CID 2011756CID-2011756, >97%
CID-2011756, >=98%
CID2011756
CID-2011756
5-(3-chlorophenyl)-N-(4-(MorpholinoMethyl)phenyl)furan-2-carboxaMide
5-(3-Chlorophenyl)-N-[4-morpholin-4-ymethyl)phenyl]furan-2-carboxamide
5-(3-Chlorophenyl)-N-[4-(4-morpholinylmethyl)phenyl]-2-furancarboxamide
5-(3-Chlorophenyl)-N-[4-(morpholin-4-ylmethyl)phenyl]furan-2-carboxamide
2-Furancarboxamide, 5-(3-chlorophenyl)-N-[4-(4-morpholinylmethyl)phenyl]-
CID-2011756,5-(3-chlorophenyl)-N-(4-(MorpholinoMethyl)phenyl)furan-2-carboxaMide
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)491.0±45.0 °C(Predicted)
密度1.297±0.06 g/cm3(Predicted)
儲(chǔ)存條件room temp
溶解度DMSO：可溶10mg/mL（澄清溶液）
酸度系數(shù)(pKa)12.54±0.70(Predicted)
形態(tài)粉末
顏色白色至米色
穩(wěn)定性可在-20°下的DMSO或乙醇溶液保存長(zhǎng)達(dá)3個(gè)月。
CID-2011756價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-13454 | CID-2011756 CID 2011756 | 638156-11-3 | 5mg | 500元 |
| 2024/11/08 | HY-13454 | CID-2011756 CID 2011756 | 638156-11-3 | 10mM * 1mLin DMSO | 550元 |
| 2024/11/08 | HY-13454 | CID-2011756 CID 2011756 | 638156-11-3 | 10mg | 750元 |
常見問(wèn)題列表
生物活性
CID 2011756是protein kinase D (PKD)的抑制劑，對(duì)PKD1、PKD2、PKD3的IC50值分別為3.2、0.6和0.7 μM。靶點(diǎn)
| Target | Value |
|
PKD2
() | 0.6 μM |
|
PKD3
() | 0.7 μM |
|
PKD1
() | 3.2 μM |
體外研究
CID 2011756 is an ATP-competitive PKD1 inhibitor, with an IC 50 of 3.2 μM. CID 2011756 decreases the phosphorylation of endogenous PKD1 Ser 916 in LNCaP cancer cells with an EC 50 of 10±0.7 μM. CID 2011756 also has cellular pan-PKD inhibitory effects, with IC 50 s of 0.6±0.1 μM and 0.7±0.2 μM for PKD2 and PKD3, respectively.