63555-63-5
63555-63-5 結(jié)構(gòu)式
基本信息
C3A (70-77),ASHLGLAR
ASHLGLAR
C3A (70-77)
complement 3a (70-77)
Complement C3a, (70-77)
ALA-SER-HIS-LEU-GLY-LEU-ALA-ARG
ANAPHYLATOXIN C3A FRAGMENT 70-77
H-ALA-SER-HIS-LEU-GLY-LEU-ALA-ARG-OH
alanine-serine-histidine-leucine-glycine-leucine-alanine-
L-Arginine, L-alanyl-L-seryl-L-histidyl-L-leucylglycyl-L-leucyl-L-alanyl-
常見問題列表
Complement system
The direct interaction of C3a(70-77) with human mononuclear leukocytes in culture results in a concentration-dependent inhibition of the generation of LIF evoked by mitogens and by the antigen SK-SD. The extent of suppression of LIF generation by C3a(70-77) is significant at concentrations of 10
-7
M or higher and exceeds 75% at 10
-6
M, irrespective of the stimulus.
C3a (70-77) induces histamine release and degranulation of rat mast cells, promotes contraction of guinea pig ileal tissue, and enhances vascular permeability in human skin. C3a (70-77) selectively desensitizes ileal smooth muscle to C3a but not to human C5a, a related anaphylatoxin. Conversely, C3a-(70-77) is unable to contract ileal smooth muscle pretreated with natural C3a. This cross-desensitization indicates a specific interaction of C3a (70-77) with cellular C3a binding sites.